Transition From Acute to Chronic Pain After Inguinal Hernia, Hysterectomy and Thoracotomy: Analysis of Risk Factors and Association With Genetic Polymorphisms
The treatment of postoperative pain continues to be inadequate in the investigators practice setting.
Inadequate pain treatment not only contributes to postoperative complications in the short term but can also be a factor that favors the development of chronic postoperative pain and diminishes long-term quality of life. Risk factors that can lead to a transition to chronic pain need to be analyzed.
|Chronic Postoperative Pain||Procedure: Inguinal herniorraphy. Procedure: Hysterectomy. Procedure: Thoracotomy .|
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Transition From Acute to Chronic Pain After Inguinal Hernia, Hysterectomy and Thoracotomy : Analysis of Risk Factors and Association With Genetic Polymorphisms|
- Evaluation of chronic postsurgical pain. [ Time Frame: After 3 and 12 months of surgery. ]After 3 months a physical examination will take place and after 12 months a follow-up will be reported by phone.
- Predictive factors of chronic postsurgical pain. [ Time Frame: After 3 and 12 months of surgery. ]Preoperative (psychological factors, preoperative pain, pharmacologic treatment) intraoperative (surgical technic, type of anaestesia) and postoperative(posoperative pain, surgical complications and treatment of postoperative pain).
Biospecimen Retention: Samples With DNA
Sample collection Five milliliters of venous blood will be extracted from each patient with chronic pain; control samples will come from a DNA bank. All patients must have given their written consent to testing and storage.
- Plasma DNA will be extracted with a BioRobot EZ1 Workstation (Qiagen).
|Study Start Date:||January 2009|
|Study Completion Date:||July 2014|
|Primary Completion Date:||December 2012 (Final data collection date for primary outcome measure)|
|Patients who had inguinal herniorraphy.||
Procedure: Inguinal herniorraphy.
Inguinal herniorraphy (non laparoscopic).
|Patients who had hysterectomy.||
Hysterectomy: Vaginal and abdominal.
|Patients who had thoracotomy.||
Procedure: Thoracotomy .
Thoracotomy (non laparoscopic).
Please refer to this study by its ClinicalTrials.gov identifier: NCT01510496
|Hospital Municipal de Badalona|
|Badalona, Barcelona, Spain, 08911|
|Hospital Universitari Germans Trias i Pujol|
|Badalona, Barcelona, Spain, 08916|
|Hospital de San Bernabé|
|Berga, Barcelona, Spain, 08600|
|Hospital de Granollers|
|Granollers, Barcelona, Spain, 08400|
|Hospital Universitari de Bellvitge|
|L'Hospitalet de Llobregat, Barcelona, Spain, 08907|
|Hospital General de Manresa|
|Manresa, Barcelona, Spain, 08240|
|Hospital de Mataro|
|Mataro, Barcelona, Spain, 08304|
|Hospital Parc Tauli|
|Sabadell, Barcelona, Spain, 08208|
|Hospital Mutua de Terrassa|
|Terrassa, Barcelona, Spain, 08221|
|Hospital Universitari Mutua de Terrassa|
|Terrassa, Barcelona, Spain, 08227|
|Hospital de Viladecans|
|Viladecans, Barcelona, Spain, 08840|
|Hospital de Santa Caterina|
|Salt, Girona, Spain, 17190|
|Hospital Sant Joan de Reus|
|Reus, Tarragona, Spain, 43201|
|Hospital Lluís Alcanyís de Xàtiva|
|Xàtiva, València, Spain, 46800|
|Hospital del Mar|
|Barcelona, Spain, 08003|
|Hospital de l'Esperança|
|Barcelona, Spain, 08024|
|Hospital de la Santa Creu i Sant Pau|
|Barcelona, Spain, 08025|
|Hospital Sagrat Cor|
|Barcelona, Spain, 08029|
|Hospital Universitari Vall d'Hebron|
|Barcelona, Spain, 08035|
|Hospital Clínic i Provincial de Barcelona|
|Barcelona, Spain, 08036|
|Hospital del Sant Boi|
|Barcelona, Spain, 08830|
|Hospital Universitari Doctor Josep Trueta de Girona|
|Girona, Spain, 17007|
|Hospital Santa Maria|
|Lleida, Spain, 25198|
|Hospital Clínico de Valencia|
|Valencia, Spain, 46010|
|Hospital General Universitario de Valencia|
|Valencia, Spain, 46014|
|Hospital Universitari de la Fe|
|Valencia, Spain, 46026|