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Vitamin D Inadequacy is Associated With Incidence of Type 2 Diabetes

This study has been completed.
Information provided by (Responsible Party):
Soo Lim, Seoul National University Bundang Hospital Identifier:
First received: January 5, 2012
Last updated: October 5, 2012
Last verified: October 2012
Emerging evidence suggests that vitamin D [25-hydroxyvitamin D; 25(OH)D] may play a role in the etiology of type 2 diabetes. Vitamin D levels are lower in those with type 2 diabetes and impaired glucose tolerance (IGT) compared with those with normal glucose tolerance (NGT). In addition, a few prospective studies have shown a significant inverse association of baseline serum 25(OH)D with incident diabetes. To date, however, the exact mechanisms through which vitamin D affects diabetes risk are not yet fully known, particularly whether vitamin D plays a role in insulin resistance (IR) and/or b-cell dysfunction, the main pathophysiological disorders underlying type 2 diabetes. So, the investigators plan to examine the prospective associations of baseline vitamin D [25-hydroxyvitamin D; 25(OH)D] with insulin resistance (IR), b-cell function, and glucose homeostasis in subjects at risk for type 2 diabetes.

Type 2 Diabetes

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Vitamin D Inadequacy is Associated With Incidence of Type 2 Diabetes

Resource links provided by NLM:

Further study details as provided by Seoul National University Bundang Hospital:

Primary Outcome Measures:
  • Incidence of diabetes [ Time Frame: 5 years ]
    Incidence of diabetes defined by American Diabetes Association criteria

Secondary Outcome Measures:
  • Pancreatic beta cell function [ Time Frame: 5 years ]
    Pancreatic beta cell function assessed by homeostasis model

  • Insulin resistance [ Time Frame: 5 years ]
    Insulin resistance assessed by homeostasis model

Biospecimen Retention:   None Retained
Blood sample was collected at the baseline.

Enrollment: 1500
Study Start Date: January 2007
Study Completion Date: October 2012
Primary Completion Date: October 2012 (Final data collection date for primary outcome measure)
Diabetes high risk group


Ages Eligible for Study:   30 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Study participants, aged over 30 years, are recruited from Korea, between January 2006 and December 2011. Participants are at high risk for type 2 diabetes, as they are recruited on the basis of the presence of one or more risk factors for diabetes, including obesity, hypertension, dislipidemia, and a family history of diabetes. Participants are contacted every 6 month after the baseline visit to update contact information and collect data on major health events. Participants are invited to return to the clinic examination centers after 3 years for follow-up assessments.

Inclusion Criteria:

  • one or more risk factors for diabetes, including:

    • obesity
    • hypertension
    • dislipidemia
    • a family history of diabetes

Exclusion Criteria:

  • previous diagnosed diabetes
  • vitamin D supplement.
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Please refer to this study by its identifier: NCT01508481

Korea, Republic of
Seoul National University Bundang Hospital
Seongnam, Korea, Republic of, 463-707
Sponsors and Collaborators
Seoul National University Bundang Hospital
Principal Investigator: Soo Lim, MD, PHD Seoul National University Bundang Hospital
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Soo Lim, Principal Investigator, Seoul National University Bundang Hospital Identifier: NCT01508481     History of Changes
Other Study ID Numbers: VitaminD_T2DM
Study First Received: January 5, 2012
Last Updated: October 5, 2012

Keywords provided by Seoul National University Bundang Hospital:
Vitamin D
pancreas beta cell function
insulin resistance
Deficiency of Vitamin D3

Additional relevant MeSH terms:
Diabetes Mellitus
Diabetes Mellitus, Type 2
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Vitamin D
Growth Substances
Physiological Effects of Drugs
Bone Density Conservation Agents processed this record on May 24, 2017