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Chocolate's Effect on the Cerebral Vasculature

This study has been completed.
University of Glasgow
Information provided by (Responsible Party):
Steven Burke, NHS Greater Glasgow and Clyde Identifier:
First received: January 6, 2012
Last updated: July 26, 2012
Last verified: July 2012

The popularity of chocolate can largely be attributed to its mood elevating properties, research shows that it contains antioxidants that also provide physical health benefits. Dark chocolate, in particular, contains high levels of an antioxidant called epicatechin, which is known to cause changes in blood vessels by relaxing them and increasing blood flow.

Little is know about the immediate effects of chocolate consumption, or the differences between milk and dark chocolate with regards to these effects. The project will investigate the effect of a single bar of dark or milk chocolate upon blood flow to the brain, using simple ultrasound tests.

Condition Intervention
Cerebral Vasculature Other: cocoa

Study Type: Observational
Study Design: Observational Model: Case-Crossover
Time Perspective: Prospective
Official Title: A Randomised Trial of Effect of Chocolate Upon Cerebrovascular Reactivity in Healthy Adult Volunteers

Further study details as provided by Steven Burke, NHS Greater Glasgow and Clyde:

Enrollment: 24
Study Start Date: February 2012
Study Completion Date: February 2012
Groups/Cohorts Assigned Interventions
100 g containing 70% or 34% cocoa
Healthy controls
Other: cocoa
70% versus 34%


Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy controls

Inclusion Criteria:

  • No regular medication including vitamins/antioxidants
  • Able to provide informed consent

Exclusion Criteria:

  • Inability to perform breath-hold test
  • Any known cardiovascular disease, diabetes, throid disease, high blood pressure, hyperlipidaemia or pregnancy
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01507259

United Kingdom
Western Infirmary
Glasgow, United Kingdom, G11 6NT
Sponsors and Collaborators
NHS Greater Glasgow and Clyde
University of Glasgow
  More Information

Responsible Party: Steven Burke, Sponsor's representative, NHS Greater Glasgow and Clyde Identifier: NCT01507259     History of Changes
Other Study ID Numbers: GN11MT497
Study First Received: January 6, 2012
Last Updated: July 26, 2012

Keywords provided by Steven Burke, NHS Greater Glasgow and Clyde:
Determine effect on cerebral vasculature processed this record on September 19, 2017