Chocolate's Effect on the Cerebral Vasculature

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01507259
Recruitment Status : Completed
First Posted : January 10, 2012
Last Update Posted : July 27, 2012
University of Glasgow
Information provided by (Responsible Party):
Steven Burke, NHS Greater Glasgow and Clyde

Brief Summary:

The popularity of chocolate can largely be attributed to its mood elevating properties, research shows that it contains antioxidants that also provide physical health benefits. Dark chocolate, in particular, contains high levels of an antioxidant called epicatechin, which is known to cause changes in blood vessels by relaxing them and increasing blood flow.

Little is know about the immediate effects of chocolate consumption, or the differences between milk and dark chocolate with regards to these effects. The project will investigate the effect of a single bar of dark or milk chocolate upon blood flow to the brain, using simple ultrasound tests.

Condition or disease Intervention/treatment
Cerebral Vasculature Other: cocoa

Study Type : Observational
Actual Enrollment : 24 participants
Observational Model: Case-Crossover
Time Perspective: Prospective
Official Title: A Randomised Trial of Effect of Chocolate Upon Cerebrovascular Reactivity in Healthy Adult Volunteers
Study Start Date : February 2012
Actual Study Completion Date : February 2012

Group/Cohort Intervention/treatment
100 g containing 70% or 34% cocoa
Healthy controls
Other: cocoa
70% versus 34%

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy controls

Inclusion Criteria:

  • No regular medication including vitamins/antioxidants
  • Able to provide informed consent

Exclusion Criteria:

  • Inability to perform breath-hold test
  • Any known cardiovascular disease, diabetes, throid disease, high blood pressure, hyperlipidaemia or pregnancy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01507259

United Kingdom
Western Infirmary
Glasgow, United Kingdom, G11 6NT
Sponsors and Collaborators
NHS Greater Glasgow and Clyde
University of Glasgow

Responsible Party: Steven Burke, Sponsor's representative, NHS Greater Glasgow and Clyde Identifier: NCT01507259     History of Changes
Other Study ID Numbers: GN11MT497
First Posted: January 10, 2012    Key Record Dates
Last Update Posted: July 27, 2012
Last Verified: July 2012

Keywords provided by Steven Burke, NHS Greater Glasgow and Clyde:
Determine effect on cerebral vasculature