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Proprioceptive Postural Control and Diaphragm Paresis

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified January 2012 by Katholieke Universiteit Leuven.
Recruitment status was:  Not yet recruiting
Universitaire Ziekenhuizen Leuven
Information provided by (Responsible Party):
Simon Brumagne, Katholieke Universiteit Leuven Identifier:
First received: January 4, 2012
Last updated: December 4, 2013
Last verified: January 2012

Proprioceptive weighting changes may explain differences in postural control performance. In addition, the respiratory movement has a disturbing effect on postural balance. Postural balance seems to be impaired in individuals with respiratory disorders. Increased risk of falling is reported in individuals with chronic obstructive pulmonary disease. Besides the essential role of respiration, the diaphragm may also play an important role in the control of the trunk and postural balance.

The aim of the study is to clarify whether proprioceptive postural control is impaired in individuals with diaphragm paresis.

Proprioceptive Postural Control
Respiratory Disorders
Chronic Obstructive Pulmonary Disease

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional

Further study details as provided by Katholieke Universiteit Leuven:

Primary Outcome Measures:
  • Proprioceptive postural control [ Time Frame: 1 year ] [ Designated as safety issue: No ]
    Center of pressure displacement (force plate) in standing in response to local muscle vibration on ankle and back muscles to specifically detect the role of proprioception in postural control.

Estimated Enrollment: 20
Study Start Date: January 2014
Estimated Study Completion Date: January 2015
Estimated Primary Completion Date: December 2014 (Final data collection date for primary outcome measure)
Diaphragm paresis
Healthy controls


Ages Eligible for Study:   18 Years to 70 Years   (Adult, Senior)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
patients from the University Hospital Leuven - Respiratory Disvision

Inclusion Criteria individuals with diaphragm paresis:

  • Age: 18-70 years old
  • Unilateral or bilateral diaphragm paresis following paresis of phrenic nerve
  • Willingness to sign the informed consent

Inclusion Criteria healthy controls:

  • Age: 18-70 years old
  • Spirometry: FEV1/FVC ≥ 0.7 and FEV1 > 80%
  • Willingness to sign the informed consent

Exclusion Criteria:

  • History of major trauma and/or major orthopedic surgery of the spine, the pelvis or the lower quadrant
  • One of the following conditions: Parkinson, multiple sclerosis, stroke, history of vestibular disorder
  • Respiratory disorder other than diaphragm paresis
  • Recent diagnosis of cancer
  • Significant cardiovascular comorbidity
  Contacts and Locations
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Please refer to this study by its identifier: NCT01505556

Katholieke Universiteit Leuven
Leuven, Vlaams-Brabant, Belgium, 3000
Sponsors and Collaborators
Katholieke Universiteit Leuven
Universitaire Ziekenhuizen Leuven
Principal Investigator: Simon Brumagne, PhD Katholieke Universiteit Leuven
Principal Investigator: Thierry Troosters, PhD Katholieke Universiteit Leuven
Principal Investigator: Wim Janssens, MD, PhD Katholieke Universiteit Leuven
Principal Investigator: Marc Decramer, MD, PhD Katholieke Universiteit Leuven
  More Information

Responsible Party: Simon Brumagne, Prof. dr. Simon Brumagne, Katholieke Universiteit Leuven Identifier: NCT01505556     History of Changes
Other Study ID Numbers: 2012_SBrumagne_DiaphParesis, G.0674.09 
Study First Received: January 4, 2012
Last Updated: December 4, 2013
Health Authority: Belgium: Ethics Committee

Additional relevant MeSH terms:
Lung Diseases
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Respiration Disorders
Respiratory Tract Diseases processed this record on December 08, 2016