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Proprioceptive Postural Control and Chronic Obstructive Pulmonary Disease (COPD)

This study has been completed.
Universitaire Ziekenhuizen Leuven
Information provided by (Responsible Party):
Simon Brumagne, Katholieke Universiteit Leuven Identifier:
First received: January 4, 2012
Last updated: December 4, 2013
Last verified: July 2012

Proprioceptive weighting changes may explain differences in postural control performance. In addition, the respiratory movement has a disturbing effect on postural balance. Postural balance seems to be impaired in individuals with respiratory disorders. Increased risk of falling is reported in individuals with chronic obstructive pulmonary disease. Besides the essential role of respiration, the diaphragm may also play an important role in the control of the trunk and postural balance.

The aim of the study is to clarify whether proprioceptive postural control is impaired in individuals with chronic obstructive pulmonary disease.

Proprioceptive Postural Control
Chronic Obstructive Pulmonary Disease

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional

Resource links provided by NLM:

Further study details as provided by Simon Brumagne, Katholieke Universiteit Leuven:

Primary Outcome Measures:
  • Proprioceptive postural control [ Time Frame: 6 months ]
    Center of pressure displacement (force plate) in standing in response to local muscle vibration on ankle and back muscles to specifically detect the role of proprioception in postural control.

Estimated Enrollment: 40
Study Start Date: January 2012
Study Completion Date: September 2012
Primary Completion Date: August 2012 (Final data collection date for primary outcome measure)
chronic obstructive pulmonary disease
healthy matched controls


Ages Eligible for Study:   40 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
patients from the University Hospital Leuven - Respiratory Disvision

Inclusion Criteria individuals with chronic obstructive pulmonary disease:

  • Age: 40-80 years old
  • Spirometry (post-bronchodilator) based diagnosis of COPD (GOLD criteria)
  • Willingness to sign the informed consent

Inclusion Criteria healthy controls:

  • Age: 40-80 years old
  • No COPD (spirometry based: FEV1/FVC ≥ 0.7 and FEV1 > 80%)
  • Willingness to sign the informed consent

Exclusion Criteria:

  • History of major trauma and/or major orthopedic surgery of the spine, the pelvis or the lower quadrant
  • One of the following conditions: Parkinson, multiple sclerosis, stroke, history of vestibular disorder
  • Respiratory disorder other than COPD
  • α1-antitrypsin deficiency
  • Known history of significant inflammatory disease other than COPD
  • COPD exacerbation within 4 weeks prior to study
  • Lung surgery
  • Recent diagnosis of cancer
  • Therapy with oral corticosteroids in the last 6 weeks
  • Significant cardiovascular comorbidity
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Please refer to this study by its identifier: NCT01505543

Katholieke Universiteit Leuven
Leuven, Vlaams-Brabant, Belgium, 3000
Sponsors and Collaborators
Katholieke Universiteit Leuven
Universitaire Ziekenhuizen Leuven
Principal Investigator: Simon Brumagne, PhD Katholieke Universiteit Leuven
Principal Investigator: Thierry Troosters, PhD Katholieke Universiteit Leuven
Principal Investigator: Wim Janssens, MD, PhD Katholieke Universiteit Leuven
Principal Investigator: Marc Decramer, MD, PhD Katholieke Universiteit Leuven
  More Information

Responsible Party: Simon Brumagne, Prof. dr. Simon Brumagne, Katholieke Universiteit Leuven Identifier: NCT01505543     History of Changes
Other Study ID Numbers: 2012_SBrumagne_COPD, G.0674.09 ( Other Grant/Funding Number: Research Foundation Flanders (FWO) )
Study First Received: January 4, 2012
Last Updated: December 4, 2013

Additional relevant MeSH terms:
Lung Diseases
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Respiratory Tract Diseases processed this record on May 25, 2017