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Proprioceptive Postural Control and Chronic Obstructive Pulmonary Disease (COPD)

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ClinicalTrials.gov Identifier: NCT01505543
Recruitment Status : Completed
First Posted : January 6, 2012
Last Update Posted : December 5, 2013
Sponsor:
Collaborator:
Universitaire Ziekenhuizen Leuven
Information provided by (Responsible Party):
Simon Brumagne, KU Leuven

Brief Summary:

Proprioceptive weighting changes may explain differences in postural control performance. In addition, the respiratory movement has a disturbing effect on postural balance. Postural balance seems to be impaired in individuals with respiratory disorders. Increased risk of falling is reported in individuals with chronic obstructive pulmonary disease. Besides the essential role of respiration, the diaphragm may also play an important role in the control of the trunk and postural balance.

The aim of the study is to clarify whether proprioceptive postural control is impaired in individuals with chronic obstructive pulmonary disease.


Condition or disease
Proprioceptive Postural Control Chronic Obstructive Pulmonary Disease

Study Type : Observational
Estimated Enrollment : 40 participants
Observational Model: Case Control
Time Perspective: Cross-Sectional
Study Start Date : January 2012
Actual Primary Completion Date : August 2012
Actual Study Completion Date : September 2012

Resource links provided by the National Library of Medicine

MedlinePlus related topics: COPD Lung Diseases

Group/Cohort
chronic obstructive pulmonary disease
healthy matched controls



Primary Outcome Measures :
  1. Proprioceptive postural control [ Time Frame: 6 months ]
    Center of pressure displacement (force plate) in standing in response to local muscle vibration on ankle and back muscles to specifically detect the role of proprioception in postural control.



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Ages Eligible for Study:   40 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
patients from the University Hospital Leuven - Respiratory Disvision
Criteria

Inclusion Criteria individuals with chronic obstructive pulmonary disease:

  • Age: 40-80 years old
  • Spirometry (post-bronchodilator) based diagnosis of COPD (GOLD criteria)
  • Willingness to sign the informed consent

Inclusion Criteria healthy controls:

  • Age: 40-80 years old
  • No COPD (spirometry based: FEV1/FVC ≥ 0.7 and FEV1 > 80%)
  • Willingness to sign the informed consent

Exclusion Criteria:

  • History of major trauma and/or major orthopedic surgery of the spine, the pelvis or the lower quadrant
  • One of the following conditions: Parkinson, multiple sclerosis, stroke, history of vestibular disorder
  • Respiratory disorder other than COPD
  • α1-antitrypsin deficiency
  • Known history of significant inflammatory disease other than COPD
  • COPD exacerbation within 4 weeks prior to study
  • Lung surgery
  • Recent diagnosis of cancer
  • Therapy with oral corticosteroids in the last 6 weeks
  • Significant cardiovascular comorbidity

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01505543


Locations
Belgium
Katholieke Universiteit Leuven
Leuven, Vlaams-Brabant, Belgium, 3000
Sponsors and Collaborators
KU Leuven
Universitaire Ziekenhuizen Leuven
Investigators
Principal Investigator: Simon Brumagne, PhD KU Leuven
Principal Investigator: Thierry Troosters, PhD KU Leuven
Principal Investigator: Wim Janssens, MD, PhD KU Leuven
Principal Investigator: Marc Decramer, MD, PhD KU Leuven

Publications:
Responsible Party: Simon Brumagne, Prof. dr. Simon Brumagne, KU Leuven
ClinicalTrials.gov Identifier: NCT01505543     History of Changes
Other Study ID Numbers: 2012_SBrumagne_COPD
1.5.104.03, G.0674.09 ( Other Grant/Funding Number: Research Foundation Flanders (FWO) )
First Posted: January 6, 2012    Key Record Dates
Last Update Posted: December 5, 2013
Last Verified: July 2012

Additional relevant MeSH terms:
Lung Diseases
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Respiratory Tract Diseases