Cardiac Energetics and Function in Normal Human Ageing
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|ClinicalTrials.gov Identifier: NCT01504828|
Recruitment Status : Completed
First Posted : January 5, 2012
Last Update Posted : March 30, 2017
|Condition or disease||Intervention/treatment||Phase|
|Left Ventricular Function Systolic Dysfunction Left Ventricular Function Diastolic Dysfunction Ageing||Drug: Ramipril||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||135 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||Cardiac Energetics and Function in Normal Human Ageing|
|Study Start Date :||July 2012|
|Actual Primary Completion Date :||December 2015|
|Actual Study Completion Date :||December 2015|
Those who are 40 years and older receive an ACE inhibitor to determine if this reduces age-related changes in left ventricular energetics and function
Ramipril in one dose to reduce vascular stiffness to determine effects of this on left ventricular function and energetics
- Vascular Stiffness [ Time Frame: 2 Hours - Acute study with no follow-up ]There are 3 principal measures of vascular stiffness, and these are central pulse pressure, central systolic pressure, and the augmentation index. These are correlated against the 3 principal measures of left ventricular function and energetics that are known to change with age: torsion to shortening ratio, early to late diastolic filling ratio, and the ratio of phosphocreatine to adenosine triphosphate (listed as separate Primary Outcome Measures).
- Left Ventricular Energetics [ Time Frame: 2 hours - Acute Study, no follow-up ]Left ventricular energetics is measured as the ratio of phosphocreatine to adenosine triphosphate
- Left Ventricular Function [ Time Frame: 2 hours - Acute Study, no follow-up ]Left ventricular function is measured with the 2 parameters that are known to change with age: ratio of early to late diastolic filling, and ratio of torsion to shortening ratio.
- Effects of ACE inhibitor on left ventricular energetics and function in those subjects aged 40 and over [ Time Frame: 6 hours - Acute study, no follow-up ]A single dose of ACE inhibitor is given to reduce vascular stiffness, and we then measure the effects of this on the measures of left ventricular function and energetics which are the torsion to shortening ratio, diastolic early to late filling ratio, and the phosphocreatine to adenosine triphosphate ratio.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01504828
|Campus for Ageing and Vitality|
|Newcastle upon Tyne, United Kingdom, NE4 6BE|
|Principal Investigator:||Guy A MacGowan, MD||Freeman Hospital, Newcastle upon Tyne and Newcastle University|