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ICU Venous Thromboembolism Incidence Study in a Chinese Population

The recruitment status of this study is unknown because the information has not been verified recently.
Verified July 2011 by National Taiwan University Hospital.
Recruitment status was  Recruiting
Information provided by (Responsible Party):
National Taiwan University Hospital Identifier:
First received: July 19, 2011
Last updated: January 4, 2012
Last verified: July 2011

Venous thromboembolism (VTE) is one of the major public health problems in Western country. More than 100,000 Americans die each year from VTE. VTE is also a common complication of critical illness,1-2 and probably related to poor outcome in this patient group. Although there are guidelines about VTE prophylaxis in acutely ill medical patients and patients in medical ICU3, they are overlooked in our daily practice frequently in our country. There are many reasons for our common practice, including inadequate knowledge for the ICU physicians, more patients with bleeding tendency in ICU and low prevalence of VTE in our (eastern) country. However, the true prevalence of VTE in ICU and if thromboprophylaxis still needed in certain high risk patients are not unknown. Besides, if there is a difference in the VTE rate between western and eastern patients, what is the underlying mechanism? The major objective of this application is to answer the first part of the problem, i.e. to delineate the scope of this problem.

The specific aims of this application are as follows:

  • prevalence of venous thromboembolism in ICU in Taiwan
  • specific risk in subgroups of ICU patients
  • prevalence and risk factors for silent pulmonary embolism

Venous Thromboembolism

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Using Inflammatory Markers to Predict the Development and Outcome of Venous Thromboembolism in an Intensive Care Unit

Resource links provided by NLM:

Further study details as provided by National Taiwan University Hospital:

Primary Outcome Measures:
  • deep venous thrombosis by ultrasound [ Time Frame: day 14 after ICU admission ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • any clinical thromboembolic event [ Time Frame: day 14 ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples Without DNA

Estimated Enrollment: 200
Study Start Date: May 2011
patinet with deep venous thrombosis
patient with deep venous thrombosis by ultrasonography as case; patient with no deep venous thrombosis by ultrasonography as control
patient without deep venous thrombosis


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
All patients admitted to ICU with age over 18 y/o are eligible

Inclusion Criteria:

  • All patients admitted to medical ICU with age over 18 y/o are eligible

Exclusion Criteria:

  • Patients who do not sign the informed consent will be excluded from this study
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01504087

Contact: Chi-sheng Hung, MD 886-972-655354

National Taiwan University Hospital Yunlin branch Recruiting
Douliu, Taiwan, 640
Contact: Chi-sheng Hung, MD         
Principal Investigator: Yung-Wei Chen, MD         
Sponsors and Collaborators
National Taiwan University Hospital
Principal Investigator: Yung-Wei Chen, MD National Taiwan University Hospital Yunlin branch
  More Information

Responsible Party: National Taiwan University Hospital Identifier: NCT01504087     History of Changes
Other Study ID Numbers: 201011022RC 
Study First Received: July 19, 2011
Last Updated: January 4, 2012
Health Authority: Taiwan: Department of Health

Keywords provided by National Taiwan University Hospital:
patient in critical care

Additional relevant MeSH terms:
Venous Thromboembolism
Embolism and Thrombosis
Vascular Diseases
Cardiovascular Diseases processed this record on October 25, 2016