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Morphological and Functional Evaluation of Irvine-Gass Syndrome

This study has been completed.
Information provided by (Responsible Party):
Marion Munk, Medical University of Vienna Identifier:
First received: December 28, 2011
Last updated: September 23, 2015
Last verified: September 2015

Purpose: To evaluate morphological and functional characteristics of Irvine Gass syndrome

Methods: 30 patients suffering on Cystoid macular edema (CME) secondary to Cataract surgery will be observed and evaluated by fluorescein-angiography, SD-OCT, reading performance, contrast sensitivity and microperimetry in a fixed time schedule

Condition Intervention
Irvine Gass Syndrome
Behavioral: if needed (decided individually) either Acular eye drops, Ultracortenol eye drop or intravitreal triamcinolone injection

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective

Resource links provided by NLM:

Further study details as provided by Medical University of Vienna:

Primary Outcome Measures:
  • Reduction of central retinal thickness [ Time Frame: 3 months ]

Secondary Outcome Measures:
  • Increase of Best corrected visual acuity [ Time Frame: 3 months ]

Enrollment: 50
Study Start Date: November 2011
Primary Completion Date: July 2014 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Patients suffering on CME secondary to cataract surgery Behavioral: if needed (decided individually) either Acular eye drops, Ultracortenol eye drop or intravitreal triamcinolone injection
if prescribed: Ultracortenol/ Acular eye drops 3-4 times a day, if prescribed: singular intravitreal triamcinolone injection


Ages Eligible for Study:   18 Years to 100 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
30 patients suffering on CME secondary to cataract surgery

Inclusion Criteria:

  • > 18 years
  • St.p Cataract surgery
  • able to read
  • informed consent
  • with fluorescein angiography and SD-OCT diagnosed Irvine Gass syndrome

Exclusion Criteria:

  • < 18 years
  • CME of other origin
  • diabetic macular edema
  Contacts and Locations
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Please refer to this study by its identifier: NCT01504074

Department of Ophthalmology Medical University of Vienna
Vienna, Austria, 1190
Sponsors and Collaborators
Medical University of Vienna
  More Information

Responsible Party: Marion Munk, MD, Principal Investigator, Department of Ophthalmology and Optometry,, Medical University of Vienna Identifier: NCT01504074     History of Changes
Other Study ID Numbers: 071/2009
Study First Received: December 28, 2011
Last Updated: September 23, 2015

Keywords provided by Medical University of Vienna:
Irvine Gass syndrome
multimodal imaging
CME secondary to cataract surgery
in vivo correlation of morphology and function

Additional relevant MeSH terms:
Macular Edema
Pathologic Processes
Macular Degeneration
Retinal Degeneration
Retinal Diseases
Eye Diseases
Triamcinolone hexacetonide
Triamcinolone Acetonide
Ketorolac Tromethamine
Triamcinolone diacetate
Ophthalmic Solutions
Anti-Inflammatory Agents
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs
Immunosuppressive Agents
Immunologic Factors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Anti-Inflammatory Agents, Non-Steroidal
Analgesics, Non-Narcotic
Sensory System Agents processed this record on May 25, 2017