Usefulness of Chromoendoscopy in Diagnosing Microscopic Colitis
Recruitment status was: Recruiting
|Chronic Diarrhoea Lymphocytic Colitis Collagenous Colitis||Procedure: Colonoscopy with Indigo-Carmine Chromoendoscopy|
|Study Design:||Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Diagnostic
|Official Title:||Prospective Study on the Usefulness of Chromoendoscopy in Detecting Microscopic Colitis in Patients Undergoing Colonoscopy Due to Chronic Watery Diarrhoea|
- Detection of microscopic colitis using chromoendoscopy [ Time Frame: 12 month ]To investigate the usefullness of chromoendoscopy in diagnosing microscopic colitis using 0.2-0.5% Indigo-Carmine dye spray. The golden standard is the results of histological examination of biopsies from the colo-rectal mucosa.
|Study Start Date:||June 2009|
|Estimated Study Completion Date:||December 2016|
|Estimated Primary Completion Date:||June 2016 (Final data collection date for primary outcome measure)|
Procedure: Colonoscopy with Indigo-Carmine Chromoendoscopy
Colonoscopy with chromoendoscopy using 0.2-0.5% Indigo-Carmine solution sprayed in five areas of the large intestine: Cecum, ascending colon, transverse colon, descending colon and rectum. Pictures are taken before and after dye-spraying and biopsies are collected from all segments of the large intestine and rectum.
Other Name: Indigo-Carmine
Microscopic colitis is a common disease found in 10% to 20% of cases having chronic watery diarrhea. Obvious endoscopically identifiable changes of the mucosal surface are usually absent, thus diagnosing microscopic colitis relies on multiple biopsy sampling from all segments of the colon. Chromoendoscopy using indigo-carmine dye spray might, however, unravel mucosal changes in microscopic colitis (Suzuki 2011).
The aim of this study is to investigate if chromoendoscopy using Indigo-Carmine 0.2-0.5% in patients with chronic watery diarrhea is useful in diagnosing microscopic colitis.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01504048
|Contact: Peter T Schmidt, MD, PhD||+46 8 firstname.lastname@example.org|
|Karoliniska University Hospital, Dept. of Gastroenterology||Recruiting|
|Stockholm, Sweden, 17176|
|Contact: Peter T Schmidt, MD, PhD +46 8 51770000 email@example.com|
|Principal Investigator: Peter T Schmidt, MD, PhD|
|Principal Investigator:||Peter T Schmidt, MD, PhD||Karolinska University Hospital|