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Biomarkers in Exhaled Breath Condensates in Acute Lung Injury: Early Detection and Outcome Predictors

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ClinicalTrials.gov Identifier: NCT01503723
Recruitment Status : Unknown
Verified September 2011 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
First Posted : January 4, 2012
Last Update Posted : January 4, 2012
Sponsor:
Information provided by (Responsible Party):
National Taiwan University Hospital

Brief Summary:
Metabolomics, or metabonomics, is a large-scale approach to monitoring as many as possible of the compounds involved in cellular processes in a single assay to derive metabolic profiles. Metabolomics allows for a global assessment of a cellular state within the context of the immediate environment, taking into account genetic regulation, altered kinetic activity of enzymes, and changes in metabolic reactions. Metabolomics may be useful for understanding metabolic imbalances and for diagnosis of human disease. The investigators plan to collect exhaled breath condensate from patients with acute lung injury. Metabolomic analysis in the patients may help us to explore some novel biomarkers for the disease diagnosis and outcome prediction.

Condition or disease Intervention/treatment
Acute Lung Injury Other: Determined by intended physician

  Show Detailed Description

Study Type : Observational
Estimated Enrollment : 300 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Biomarkers in Exhaled Breath Condensates in Acute Lung Injury: Early Detection and Outcome Predictors
Study Start Date : August 2011


Group/Cohort Intervention/treatment
Patients with acute lung injury
Patients who are admitted to ICU with the diagnosis of acute hypoxemic respiratory failure
Other: Determined by intended physician
We perform a prospective observational study. All the treatment for the patients are determined by intended physicians.



Primary Outcome Measures :
  1. Diagnosis [ Time Frame: 28 days ]
    To differentiate ALI/ARDS from cardiogenic pulmonary edema or other causes

  2. Disease severity [ Time Frame: 28 days ]

Biospecimen Retention:   Samples Without DNA
Exhaled breath condensate


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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients who are admitted to ICU with the diagnosis of acute hypoxemic respiratory failure and endotracheally intubated with mechanical ventilation.
Criteria

Inclusion Criteria:

  • above 18 years old
  • admitted to ICU with the diagnosis of acute hypoxemic respiratory failure and endotracheally intubated with mechanical ventilation.

Exclusion Criteria:

  • pregnancy

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01503723


Contacts
Contact: Lu-Cheng Kuo, MD, Master 886-2-23562905 kuolc@ntu.edu.tw

Locations
Taiwan
National Taiwan University Hospital Recruiting
Taipei, Taiwan
Contact: Lu-Cheng Kuo, MD, Master    886-2-23562905    kuolc@ntu.edu.tw   
Principal Investigator: Lu-Cheng Kuo, MD, Master         
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Principal Investigator: Lu-Cheng Kuo, MD, Master National Taiwan University Hospital

Responsible Party: National Taiwan University Hospital
ClinicalTrials.gov Identifier: NCT01503723     History of Changes
Other Study ID Numbers: 201103016RC
First Posted: January 4, 2012    Key Record Dates
Last Update Posted: January 4, 2012
Last Verified: September 2011

Additional relevant MeSH terms:
Wounds and Injuries
Lung Injury
Acute Lung Injury
Respiratory Distress Syndrome, Adult
Lung Diseases
Respiratory Tract Diseases
Thoracic Injuries
Respiration Disorders