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Trial record 45 of 158 for:    genetics AND Parkinson's disease

A Longitudinal Study in 1st Degree Relatives of Parkinson's Disease (PD) Patients

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ClinicalTrials.gov Identifier: NCT01502384
Recruitment Status : Unknown
Verified December 2011 by Tel-Aviv Sourasky Medical Center.
Recruitment status was:  Not yet recruiting
First Posted : December 30, 2011
Last Update Posted : December 30, 2011
Sponsor:
Collaborators:
Beth Israel Medical Center
Columbia University
Information provided by (Responsible Party):
Tel-Aviv Sourasky Medical Center

Brief Summary:
This is a longitudinal study in healthy 1st degree relatives of patients with Parkinson's Disease (PD) carriers of a genetic mutation in genes that are known to increase the risk for PD. The purpose of this study is to explore the association between genetic mutations in the known genes and early preclinical symptoms such as motor, sensory, autonomic, behavioral and cognitive functions.

Condition or disease Intervention/treatment
Parkinson's Disease Other: neurological examination

Study Type : Observational
Estimated Enrollment : 100 participants
Observational Model: Cohort
Study Start Date : January 2012
Estimated Primary Completion Date : June 2015

Resource links provided by the National Library of Medicine


Group/Cohort Intervention/treatment
healthy relatives
healthy 1st degree relatives of PD patients
Other: neurological examination
motor and cognitive functions





Information from the National Library of Medicine

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Ages Eligible for Study:   35 Years to 85 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy 1ST degree realtives of PD patients
Criteria

Inclusion Criteria:

  • healthy 1ST degree relatives of PD patients with known genotype that participated in an earlier genetic study at the sourasky medical center.

Exclusion Criteria:

  • subjects with cognitive decline by the parameters defined in DSM- IV
  • subjects with psychiatric disorder
  • subjects unable to sign a consent form

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01502384


Contacts
Contact: Anat Mirelman, PhD 972-3-6974958 anatmi@tasmc.health.gov.il

Locations
Israel
Tel Aviv Sourasky Medical Center Not yet recruiting
Tel Aviv, Israel
Contact: Anat Mirelman, PhD    972-3-6974958    anatmi@tasmc.health.gov.il   
Principal Investigator: Nir Giladi, MD, PhD         
Sponsors and Collaborators
Tel-Aviv Sourasky Medical Center
Beth Israel Medical Center
Columbia University

Publications:

Responsible Party: Tel-Aviv Sourasky Medical Center
ClinicalTrials.gov Identifier: NCT01502384     History of Changes
Other Study ID Numbers: TASMC-11-NG-0463
First Posted: December 30, 2011    Key Record Dates
Last Update Posted: December 30, 2011
Last Verified: December 2011

Keywords provided by Tel-Aviv Sourasky Medical Center:
healthy 1st degree relatives of pd patients

Additional relevant MeSH terms:
Parkinson Disease
Parkinsonian Disorders
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Movement Disorders
Neurodegenerative Diseases