Pulmonary Fibrosis and Telomerase Mutation Study
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT01501578|
Recruitment Status : Completed
First Posted : December 29, 2011
Last Update Posted : February 20, 2018
This study is an observational and retrospective study of patients with pulmonary fibrosis associated or not with telomerase mutation.
The purpose of this study is to describe in detail the cases with telomerase mutation in terms of features on CT scan, respiratory function and evolution, in comparison to control subjects with idiopathic pulmonary fibrosis and no telomerase mutation identified or family history.
|Condition or disease|
Two "control" subjects will be enrolled for one subject with telomerase mutation.
The data are all the results of investigations conducted for the diagnosis of idiopathic pulmonary fibrosis and during routine follow up of patients.
The CT scans will reviewed centrally to homogenize the description.
|Study Type :||Observational|
|Actual Enrollment :||81 participants|
|Official Title:||Phenotype of Pulmonary Fibrosis Associated With a Mutation of Telomerase|
|Study Start Date :||December 2011|
|Actual Primary Completion Date :||June 2012|
|Actual Study Completion Date :||December 2015|
Patients with interstitial lung disease and telomerase mutation
Patients with idiopathic pulmonary fibrosis and without telomerase mutation
- Description of imaging pattern [ Time Frame: at baseline only ]Description of imaging pattern on representative CT scan at diagnosis.
- Pathology of the lung [ Time Frame: at baseline only ]description of pathological pattern
- Pulmonary function tests [ Time Frame: from diagnosis to last follow-up, for an average of one year ]analyze the respiratory function
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01501578
|Louis Pradel Hospital (Bâtiment A4)|
|Lyon, France, 69677|
|Principal Investigator:||vincent Cottin, MD||Hospices civils de Lyon / University Lyon I|