Maintenance Plasma Exchange for Neuromyelitis Optica (MultiPLEX)
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ClinicalTrials.gov Identifier: NCT01500681 |
Recruitment Status
:
Active, not recruiting
First Posted
: December 28, 2011
Last Update Posted
: March 22, 2017
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Condition or disease | Intervention/treatment |
---|---|
Neuromyelitis Optica Neuromyelitis Optica Spectrum Disorder Recurrent Idiopathic Longitudinally Extensive Transverse Myelitis | Procedure: Plasma exchange (PLEX) |
Study Type : | Observational |
Estimated Enrollment : | 14 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Official Title: | A Prospective Observational Study of Maintenance Plasma Exchange (PLEX) for Neuromyelitis Optica Spectrum Disorders (MultiPLEX Study) |
Study Start Date : | June 2012 |
Estimated Primary Completion Date : | August 2017 |

Group/Cohort | Intervention/treatment |
---|---|
Maintenance PLEX |
Procedure: Plasma exchange (PLEX)
Regular maintenance PLEX courses, typically 3 procedures monthly
|
- Number of participants who complete planned maintenance PLEX regimen [ Time Frame: One year ]
- Number of participants with adverse events [ Time Frame: One year ]
- Annualized clinical relapse rate [ Time Frame: One year ]
- Median Expanded Disability Status Score (EDSS) [ Time Frame: One year ]

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Ages Eligible for Study: | 18 Years and older (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- Neuromyelitis optica
- Neuromyelitis optica spectrum disorder
- Recurrent idiopathic longitudinally extensive myelitis
- Age 18 years or greater
Exclusion Criteria:
- Any condition that in the opinion of the investigator could increase a participant's risk by participating in the observational study or confound the outcome of the study

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01500681
United States, Arizona | |
Mayo Clinic | |
Scottsdale, Arizona, United States, 85259 | |
United States, Minnesota | |
Mayo Clinic | |
Rochester, Minnesota, United States, 55905 |
Principal Investigator: | Dean M Wingerchuk, MD | Mayo Clinic |
Responsible Party: | Dean Wingerchuk, Principal Investigator, Mayo Clinic |
ClinicalTrials.gov Identifier: | NCT01500681 History of Changes |
Other Study ID Numbers: |
10-007339 MultiPLEX-2012 |
First Posted: | December 28, 2011 Key Record Dates |
Last Update Posted: | March 22, 2017 |
Last Verified: | March 2017 |
Additional relevant MeSH terms:
Neuromyelitis Optica Myelitis Myelitis, Transverse Demyelinating Autoimmune Diseases, CNS Autoimmune Diseases of the Nervous System Nervous System Diseases Optic Neuritis Optic Nerve Diseases Cranial Nerve Diseases Demyelinating Diseases Eye Diseases |
Autoimmune Diseases Immune System Diseases Central Nervous System Infections Central Nervous System Diseases Spinal Cord Diseases Paraneoplastic Syndromes, Nervous System Nervous System Neoplasms Neoplasms by Site Neoplasms Paraneoplastic Syndromes Neurodegenerative Diseases |