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Effects of Different I:E Ratio on Intrapulmonary Shunt Fraction and Oxygenation During One Lung Ventilation in the Lateral Decubitus Position

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ClinicalTrials.gov Identifier: NCT01499212
Recruitment Status : Completed
First Posted : December 26, 2011
Last Update Posted : December 26, 2011
Sponsor:
Information provided by (Responsible Party):
Yonsei University

Brief Summary:
The purpose of this study is to investigate effect of increasing inspiratory time (I:E ratio 1:1) on intrapulmonary shunt fraction and oxygenation during one lung ventilation in the lateral decubitus position.

Condition or disease Intervention/treatment Phase
Lung Cancer Lung Lobectomy Procedure: I:E ratio Not Applicable

Detailed Description:
Increasing inspiratory time(e.g. Inverse ratio ventilation) has been known that had advantage of alveolar recruitment, preventing of ateletasis. On the contrary, it has disadvantange of intrinsic PEEP, air trapping. There is few study on one lung ventilation in lateral decubitus position about this ventilation method. We were going to investigate effecf of this ventilation method.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 58 participants
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Effects of Different Inspiratory to Expiratory Ratios on Intrapulmonary Shunt Fraction and Oxygenation During One Lung Ventilation in the Lateral Decubitus Position
Study Start Date : July 2011
Actual Primary Completion Date : November 2011
Actual Study Completion Date : December 2011

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Pressure Sores
U.S. FDA Resources

Arm Intervention/treatment
Experimental: I:E ratio 1:1 Procedure: I:E ratio
I:E ratio 1:1 Volume controlled ventilation TV:8ml/kg EtCO2:35-40mmHg



Primary Outcome Measures :
  1. intrapulmonary shunt fraction [ Time Frame: T1 (10min before one lung ventibation)T2 (30min after one lung ventilation started)T3 (60min after one lung ventilation started)T4 (10min after two lung ventilation) ]
    T1,T2,T3,T4 : ALL mesurement in lateral decubitus position T1-intrapulmonary shunt T2-intrapulmonary shunt T3-intrapulmonary shunt T4-intrapulmonary shunt


Secondary Outcome Measures :
  1. Respiratory dynamic parameters [ Time Frame: T1,T2,T3,T4 (same as primary outcome measure) ]
    Mechanical Ventilator measurement : Paw, Pplat, Pmean, Compliance



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Ages Eligible for Study:   40 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • ASA physical status class I, II
  • Use of Double lumen tube
  • Unilateral lung lobectomy

Exclusion Criteria:

  • COPD
  • CAOD
  • Unstable hemodynamic status
  • Peak airway pressure > 30mmHg (Two lung ventilation)

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01499212


Locations
Korea, Republic of
Department of Anaesthesiology and Pain Medicine, Anaesthesia and Pain Research Institute, Yonsei University College of Medicine
Seoul, Korea, Republic of, 120-752
Sponsors and Collaborators
Yonsei University
Investigators
Study Chair: Young Jun Oh, MD,PhD Department of Anaesthesiology and Pain Medicine, Anaesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea

Responsible Party: Yonsei University
ClinicalTrials.gov Identifier: NCT01499212     History of Changes
Other Study ID Numbers: 1-2011-0058
First Posted: December 26, 2011    Key Record Dates
Last Update Posted: December 26, 2011
Last Verified: December 2011