Blood Pressure and Brain Blood Flow Regulation After Midodrine Administration in Those With Spinal Cord Injury
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This project aims to evaluate the physiological effects of Midodrine administration during orthostatic challenge in those with high level spinal cord injury. Midodrine has been shown to improve orthostatic symptoms in those with spinal cord injury but the physiological mechanisms influenced have not been identified. The investiagtors will examine key physiological components influencing orthostatic tolerance. The investiagtors will do this, by measuring the baroreflex, and brain blood flow autoregulation (the ability to maintain brain blood flow) before during and after the sit-up test. Two sit-up tests will occur; one before Midodrine administration, and one after administration of a 10mg dose of Midodrine.
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Ages Eligible for Study:
18 Years to 49 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Individuals with spinal cord injury currently in primary care (less than one year post injury)
To be included in the study, participants must have sustained a traumatic spinal cord injury within the ages of 18-49 years.
Also, participants must have an injury level above the 6th thoracic vertebrae and be a non-smoker for a minimum of one year.
Any participants with a history of cardiovascular disease, pulmonary disease or diabetes mellitus will not be eligible.
Also, participants will not be eligible to take part in study if they experiences acute distress, or are taking medications known to influence cardiovascular function.
Patient will be not eligible for the study if he/she has known adverse reaction to Midodrine.
Keywords provided by University of British Columbia:
Orthostatic intolerance in people with spinal cord injury
Additional relevant MeSH terms:
Spinal Cord Injuries
Spinal Cord Diseases
Central Nervous System Diseases
Nervous System Diseases
Trauma, Nervous System
Wounds and Injuries
Autonomic Nervous System Diseases
Signs and Symptoms
Peripheral Nervous System Agents
Physiological Effects of Drugs
Adrenergic alpha-1 Receptor Agonists
Molecular Mechanisms of Pharmacological Action