Endophthalmitis Cultures (PROSPER)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01496794
Recruitment Status : Terminated (poor enrollment)
First Posted : December 21, 2011
Last Update Posted : February 23, 2017
Information provided by (Responsible Party):
Stephen J. Kim, MD, Vanderbilt University

Brief Summary:

The intent of this surveillance study will be to obtain written permission from patients with bacterial endophthalmitis in order to compare sterilization rates of their cultured bacterial isolates to standard therapy (vancomycin and ceftazidime) versus combination therapy with vancomycin, ceftazidime, and moxifloxacin.

Research hypothesis:

  1. Cultured bacterial isolates will demonstrate faster in vitro sterilization rates with combination treatment (vancomycin, ceftazidime, and moxifloxacin) compared to "standard therapy" with vancomycin and ceftazidime.
  2. Longitudinal analysis of resistance patterns of cultured isolates will show increasing rates of multi-antibiotic resistance.

Condition or disease

Detailed Description:
Adult patients over 18 years of age presenting with endophthalmitis and able to sign consent.

Study Type : Observational
Actual Enrollment : 3 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Prospective Surveillance of Patients With Endophthalmitis for Multi-antibiotic Resistance (PROSPER) Study
Study Start Date : October 2011
Actual Primary Completion Date : April 2016
Actual Study Completion Date : April 2016

Endophthalmitis cultures

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Vanderbilt Eye Institute

Inclusion Criteria:

  • all adult patients age 18 or greater presenting with bacterial endophthalmitis to the Vanderbilt Eye Institute and who grow positive cultures

Exclusion Criteria:

  • Patients < 18 years of age or those patients without positive cultures

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01496794

United States, Tennessee
Vanderbilt Eye Institute
Nashville, Tennessee, United States, 37232
Sponsors and Collaborators
Vanderbilt University
Principal Investigator: Stephen J Kim, MD Vanderbilt University Medical Center

Responsible Party: Stephen J. Kim, MD, Assistant Professor of Ophthalmology, Vanderbilt University Identifier: NCT01496794     History of Changes
Other Study ID Numbers: 100487
First Posted: December 21, 2011    Key Record Dates
Last Update Posted: February 23, 2017
Last Verified: February 2017

Additional relevant MeSH terms:
Eye Infections
Eye Diseases