Nottingham Osteoarthritis Biomarker Study 2011
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|ClinicalTrials.gov Identifier: NCT01495455|
Recruitment Status : Completed
First Posted : December 20, 2011
Last Update Posted : January 30, 2013
Osteoarthritis is by far the most common joint condition and the single largest cause of disability in the older population. The investigators still have a poor understanding of the nature of osteoarthritis and factors that influence its development and progression. Identification of biochemical markers that relate to cartilage loss, bony overgrowth and other features that occur with osteoarthritis will advance our understanding. Over the last 5 years analytical methods have developed to measure a range of different biomarkers. This pilot study will use these analytical methods to measure biomarker levels in joint fluid, urine and blood of 50 participants with Osteoarthritis (OA) and 50 healthy volunteers.
This study will provide novel pilot data on the changes in the composition of the synovial fluid, urine and blood in patients with OA. Apart from being a key target site for OA, the knee is a suitable joint for study because of its accessibility to clinical assessment, joint aspiration and imaging.
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||140 participants|
|Observational Model:||Case Control|
|Official Title:||Nottingham Osteoarthritis Biomarker Study 2011|
|Study Start Date :||February 2012|
|Actual Primary Completion Date :||January 2013|
|Actual Study Completion Date :||January 2013|
|No knee pain/osteoarthritis|
- Difference in the levels of pro-inflammatory and anti-inflammatory lipids mediators between individuals with knee osteoarthritis and those with normal knees. [ Time Frame: within 6 months of recruitment of last participant ]
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01495455
|Academic Rheumatology, University of Nottingham|
|Nottingham, United Kingdom, NG5 1PB|
|Principal Investigator:||Michael Doherty, MA MB FRCP||University of Nottingham|