Markers of Coronary Artery Disease During Exercise Testing (CADENCE)
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|ClinicalTrials.gov Identifier: NCT01495091|
Recruitment Status : Recruiting
First Posted : December 19, 2011
Last Update Posted : September 12, 2012
|Condition or disease|
|Coronary Artery Disease Cardiovascular Disease|
Chest pain/discomfort is a common patient complaint in patients referred to outpatient clinics and emergency departments. The initial goal of evaluation is to exclude potential life threatening conditions like coronary artery disease. Exercise stress testing is a widely available non-invasive test in patients with chest pain and suspected coronary artery disease. However, the sensitivity and specificity of the test is relatively low. Exercise seems to cause an increase in the secretion of B-type natriuretic peptide (BNP), and myocardial ischemia may lead to an even more pronounced increase. Investigators aim to examine whether changes in bloodborne biomarkers such as NT-pro-BNP during exercise may improve the accuracy of exercise stress testing in patients with chest pain/discomfort and a clinical suspicion of coronary artery disease. Also, investigators aim to examine whether changes in biomarkers during exercise are related to cardiac disease demonstrated by echocardiography.
It is known that sudden heavy physical load can trigger myocardial infarction, especially in untrained individuals. The underlying mechanisms are poorly understood and may partly be related to changes in inflammation and haemostasis in patients with coronary artery disease. By measuring markers of inflammation and haemostasis during exercise stress testing, investigators hope to gain new insights into mechanisms responsible for exercise-related myocardial infarction.
Investigators also aim to do a follow-up study to investigate whether results of the initial examinations can relate to future risk of cardiovascular morbidity and mortality.
|Study Type :||Observational|
|Estimated Enrollment :||600 participants|
|Official Title:||Markers of Coronary Artery Disease During Exercise Testing|
|Study Start Date :||December 2011|
|Estimated Primary Completion Date :||December 2014|
|Estimated Study Completion Date :||December 2040|
- Coronary artery disease demonstrated by coronary angiography [ Time Frame: baseline ]
- Future cardiovascular morbidity and mortality [ Time Frame: Up to 29 years ]Investigators aim to do a follow-up study some years after enrollment to examine whether the results of the initial examinations can relate to future cardiovascular morbidity or mortality.
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01495091
|Contact: Arnljot Flaa, MD PhD||+47 firstname.lastname@example.org|
|Contact: Hilde Ulsaker, MD||+47 email@example.com|
|Oslo University Hospital||Recruiting|
|Oslo, Norway, 0407|
|Contact: Hilde Ulsaker, MD +4722119442 firstname.lastname@example.org|
|Study Chair:||Arnljot Flaa, MD PhD||Oslo University Hospital|
|Principal Investigator:||Hilde Ulsaker, MD||Oslo University Hospital and University of Oslo|
|Study Director:||Eivind Berge, MD PhD||Oslo University Hospital|
|Study Director:||Ingebjørg Seljeflot, Professor PhD||Oslo University Hospital and University of Oslo|