Management of Acute Myocardial Infarction in the Presence of Left Bundle Branch Block
Recruitment status was Not yet recruiting
|Study Design:||Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
- mortality [ Time Frame: 30 days ] [ Designated as safety issue: Yes ]
- Number of participants survived [ Time Frame: 1 year ] [ Designated as safety issue: Yes ]
|Study Start Date:||January 2012|
|Estimated Study Completion Date:||November 2013|
|Estimated Primary Completion Date:||June 2013 (Final data collection date for primary outcome measure)|
Current recommendations on the treatment of acute coronary syndrome (ACS) dictate urgent reperfusion therapy in the case of evolving myocardial infarction with ST-segment elevation (STEMI). Optimal use of PCI (preferably) or thrombolysis in this situation requires a rapid and correct diagnosis.
According to the ESC'2008 and ACC/AHA'2009 focused update guidelines patients admitted to the hospital within 12 hours after the onset of chest pain with new (or presumably new) left bundle-branch block (LBBB) should be treated like patients having STEMI (class I, level A). However, it is well-known that in patients with concomitant LBBB, the ECG manifestations of acute myocardial injury may be masked.
ACS may occur in a patient with "true old" LBBB (when doctor has/has not an ability to compare the new ECG with the previous one) or (presumably) new LBBB.
There is a high risk of non receiving appropriate therapy or of receiving inappropriate therapy (thrombolysis instead of LMWH/UFH/fondaparinux).
Please refer to this study by its ClinicalTrials.gov identifier: NCT01494870
|Contact: Dmitry Duplyakov, MD, PhDemail@example.com|
|Contact: Igor Yavelov, MD, PhDfirstname.lastname@example.org|
|Samara Regional Cardiology Dispansery||Not yet recruiting|
|Samara, Russian Federation, 443070|
|Principal Investigator: Dmitry Duplyakov, MD, PhD|