Biomarkers in Tumor Samples From Younger Patients With Neuroblastoma
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT01493830|
Recruitment Status : Completed
First Posted : December 16, 2011
Last Update Posted : July 11, 2016
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research trial studies biomarkers in tumor samples from younger patients with neuroblastoma.
|Condition or disease||Intervention/treatment|
|Neuroblastoma||Genetic: fluorescence in situ hybridization Genetic: gene expression analysis Genetic: microarray analysis Genetic: mutation analysis Genetic: protein analysis Other: immunohistochemistry staining method Other: laboratory biomarker analysis Other: microscopy|
- To determine the expression of UBE4B, hrs, and members of the ubiquitination protein complex in previously banked primary neuroblastoma tumor samples from the Children's Oncology Group.
- To determine the correlation of expression levels and cellular localization of the UBE4B and hrs proteins with growth factor-receptor tumor cell-surface expression.
- To determine the 1p36 deletion status by fluorescence in situ hybridization (FISH) analysis and their association with expression levels of UBE4B and hrs in previously banked primary neuroblastoma tumor samples from the Children's Oncology Group.
OUTLINE: Banked tumor tissue samples are analyzed for expression of UBE4B, hrs, members of the ubiquitination protein complex, growth factor receptors, and 1p36 deletion status by immunohistochemistry (IHC), fluorescent microscopy, and fluorescence in situ hybridization (FISH).
|Study Type :||Observational|
|Estimated Enrollment :||5 participants|
|Official Title:||Proposed Studies on the Role of Growth Factor Receptor Trafficking in Neuroblastoma Pathogenesis|
|Study Start Date :||December 2011|
|Actual Primary Completion Date :||July 2016|
- Expression of UBE4B, hrs, and members of the ubiquitination protein complex
- Expression levels and cellular localization of the UBE4B, hrs, and growth factor receptors
- 1p36 deletion status and its association with UBE4B
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01493830
|Principal Investigator:||Peter Zage, MD, PhD||Texas Children's Cancer Center|