Imaging the Dopamine Systems in Bulimia Nervosa

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01493362
Recruitment Status : Completed
First Posted : December 16, 2011
Last Update Posted : August 15, 2014
National Institute of Mental Health (NIMH)
Information provided by (Responsible Party):
New York State Psychiatric Institute

Brief Summary:
This study will use positron emission tomography imaging to investigate the dopamine systems in people with bulimia nervosa.

Condition or disease
Eating Disorders

Study Type : Observational
Actual Enrollment : 33 participants
Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Imaging the Dopamine Systems in Bulimia Nervosa
Study Start Date : January 2008
Actual Primary Completion Date : December 2013
Actual Study Completion Date : December 2013

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Participants with Bulimia Nervosa
Participants who are healthy controls

Primary Outcome Measures :
  1. D2 receptor density [ Time Frame: Measured at baseline ]
  2. DA release in the striatum [ Time Frame: Measures after Mythlyphenidate challenge ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
The study population will include people with bulimia nervosa seeking inpatient or outpatient treatment and people who will act as healthy control participants

Inclusion Criteria:

Participants with BN:

  • Meets DSM-IV criteria for BN
  • Sufficiently medically and psychiatrically stable to participate in research

Health Control Participants:

  • No current or past psychiatric illness
  • Between 80% and 120% of ideal body weight

Exclusion Criteria:

All participants:

  • Current use of psychotropic medication such as anti psychotics or antidepressants
  • Pregnant or breastfeeding
  • history of substance abuse
  • Significant medical illness
  • High blood pressure (resting systolic blood pressure greater than 150mmHg and diastolic blood pressure greater that 90 mmHg)
  • Current or lifetime history of schizophrenia, bipolar disorder, or other psychotic disorder as defined by DSM-IV
  • Metal implants or paramagnetic objects contained within the body that may interfere with the MRI scan, as determined in consultation with a neuroradiologist and according to specified reference book guidelines
  • Exposed to radiation in the workplace or has had a nuclear medicine procedure during the 1 year before study entry
  • Previous adverse reaction to psycho stimulants

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01493362

United States, New York
New York State Psychiatric Institute
New York, New York, United States, 10032
Sponsors and Collaborators
New York State Psychiatric Institute
National Institute of Mental Health (NIMH)

Responsible Party: New York State Psychiatric Institute Identifier: NCT01493362     History of Changes
Other Study ID Numbers: #5175
R01MH079397 ( U.S. NIH Grant/Contract )
First Posted: December 16, 2011    Key Record Dates
Last Update Posted: August 15, 2014
Last Verified: November 2011

Keywords provided by New York State Psychiatric Institute:
Bulimia Nervosa
PET Imaging

Additional relevant MeSH terms:
Feeding and Eating Disorders
Bulimia Nervosa
Mental Disorders
Signs and Symptoms, Digestive
Signs and Symptoms
Dopamine Agents
Cardiotonic Agents
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Protective Agents