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Different Endurance Training Protocols in Cardiac Rehabilitation

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ClinicalTrials.gov Identifier: NCT01493193
Recruitment Status : Completed
First Posted : December 15, 2011
Last Update Posted : August 1, 2013
Sponsor:
Information provided by (Responsible Party):
Prof. Josef Niebauer M.D., Ph.D., MBA, Paracelsus Medical University

Brief Summary:

It is the aim of the study to compare the effects of 6 weeks of either high-intensity interval training (HIT; carried out at correctly assessed 85-95% of maximal heart rate), pyramid, or continuous endurance training, on changes of physical exercise capacity in cardiac patients.

The three exercise arms (isocaloric) are composed as follows:

Endurance training (n=15): 31min at 65-75% HRmax; HIT (n=15): 4x4min intervals at 85-95% HRmax divided by 3x3min of active recovery at 60-70% HRmax, making it a total of 25min; Pyramids (n=15): One Pyramid consists of 8 one-minute blocks. Those are grouped starting with one block of 70-75% HRmax, followed by one block at 75-80% HRmax and another one at 80-85% HRmax. The top of the pyramid are 2 blocks of 85-90% HRmax. Intensity is lowered afterwards with one block at 80-85% HRmax, followed by one block at 75-80% HRmax and last one at 70-75% HRmax. Two more pyramids follow, each divided by 2min of active recovery at 65-70% HRmax, making it a total of 28min.

All protocols are initiated by 5min of warm-up and end with 5min of cool-down, both at 60-70% HRpeak.

Primary Outcome: Individual maximum power output in watt (Pmax). Secondary Outcome: Change of power output in watt at lactate thresholds at 2 and 4 mmol/l.


Condition or disease Intervention/treatment Phase
Coronary Artery Disease Other: Endurance training with constant work load Other: Pyramid-Training Other: High-intensity interval training Phase 4

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 60 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Effects of Different Endurance Training Protocols on Physical Performance in Cardiac Patients
Study Start Date : November 2011
Actual Primary Completion Date : February 2013
Actual Study Completion Date : May 2013

Arm Intervention/treatment
Active Comparator: Endurance training with constant work load Other: Endurance training with constant work load
Endurance training with constant work load(n=15): 31min at 65-75% HRmax
Experimental: Pyramid-Training Other: Pyramid-Training
Pyramid-Training (n=15): One Pyramid consists of 8 one-minute blocks. Those are grouped starting with one block of 70-75% HRmax, followed by one block at 75-80% HRmax and another one at 80-85% HRmax. The top of the pyramid are 2 blocks of 85-90% HRmax. Intensity is lowered afterwards with one block at 80-85% HRmax, followed by one block at 75-80% HRmax and last one at 70-75% HRmax. Two more pyramids follow, each divided by 2min of active recovery at 65-70% HRmax, making it a total of 28min.
Experimental: High-intensity interval training Other: High-intensity interval training
HIT (n=15): 4x4min intervals at 85-95% HRmax divided by 3x3min of active recovery at 60-70% HRmax, making it a total of 25min



Primary Outcome Measures :
  1. Individual maximum power output in watt (Pmax) [ Time Frame: 6 weeks ]
    Change of individual maximum power output in watt (Pmax) on a bicycle ergometer after the training intervention of controlled physical activity within 6 weeks


Secondary Outcome Measures :
  1. Power output in watt at lactate threshold of 2 and 4 mmol/l [ Time Frame: 6 weeks ]
    Change of power output in watt at lactate thresholds at 2 and 4 mmol/l



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Ages Eligible for Study:   25 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

At least one of the following diagnoses within the previous 3 months:

  • acute coronary syndrome (STEMI)
  • acute coronary syndrome (NSTEMI)
  • aortocoronary bypass surgery
  • PCI
  • stable coronary heart disease

Exclusion Criteria:

  • Unstable angina pectoris
  • Heart failure (NYHA IV)
  • Acute endomyocarditis or other acute infections
  • Pulmonary artery embolism or phlebothrombosis within the previous 6 months
  • Hemodynamically unstable arrhythmia
  • Hypertrophic cardiomyopathy
  • participation in another study within the previous 6 months
  • Medical conditions which prevent patients from complying with the exercise program

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01493193


Locations
Austria
Department of Sports Medicine, Prevention and Rehabilitation Paracelsus Medical University
Salzburg, Austria, 5020
Sponsors and Collaborators
Paracelsus Medical University
Investigators
Study Chair: Josef Niebauer, MD, PhD, MBA Paracelsus Medical University
Principal Investigator: Marcus Tschentscher, MSc Paracelsus Medical University

Additional Information:
Publications:

Responsible Party: Prof. Josef Niebauer M.D., Ph.D., MBA, Primar, Paracelsus Medical University
ClinicalTrials.gov Identifier: NCT01493193     History of Changes
Other Study ID Numbers: UISM-5
First Posted: December 15, 2011    Key Record Dates
Last Update Posted: August 1, 2013
Last Verified: July 2013

Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases
Cardiovascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases