NAVADYN11 : Hemodynamic Impact of a New Ventilatory Support Mode With Diaphragmatic Synchronization
Despite spectacular advances since the 90s mechanical ventilation used in intensive care units are amply associated with cardio-respiratory complications: nosocomial pneumonia, lung parenchyma lesions induced by ventilation, hemodynamic instability and ultimately to a significant morbidity and mortality.
NAVA (Neurally Adjusted Assist Ventilation) ventilatory support, provides synchronous support, proportionate to patient's respiratory efforts. More "physiological", this mode would decline its efficacy on patient hemodynamic response. However, to date, no study has focused on hemodynamic impact of NAVA. This is precisely the purpose of NAVADYN11 study, which aims to assess NAVA efficacy on cardiac index in pediatric intensive care unit.
|Invasive Ventilatory Support||Other: collection of clinical and biological parameters Other: assign optimal ventilatory mode|
|Study Design:||Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Health Services Research
|Official Title:||NAVADYN11 : Hemodynamic Impact of a New Ventilatory Support Mode With Diaphragmatic Synchronization|
- Assess the impact of NAVA ventilation on hemodynamic parametersAssess the impact of NAVA ventilation on hemodynamic parameters in children hospitalized in a Paediatric Intensive Care Unit. Endpoint evaluation consists in a non-invasive measurement of cardiac index by esophageal doppler.
- Omega scoreSaO2/SaO2-SvO2
- Heart rate
- Blood pressure
- Blood gas
- Perfusion score
- Right cardiac work indexif available
|Study Start Date:||November 2011|
Other: collection of clinical and biological parameters
Please refer to this study by its ClinicalTrials.gov identifier: NCT01490710
|Nantes University Hospital|
|Nantes, France, 44093|
|Principal Investigator:||Nicolas JORAM, Doctor||Nantes University Hospital|