TREM-1 Gene Polymorphisms

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01490424
Recruitment Status : Completed
First Posted : December 13, 2011
Last Update Posted : December 13, 2011
Information provided by:
Chinese PLA General Hospital

Brief Summary:
Triggering receptor expressed on myeloid cells-1 (TREM-1) is a cell surface receptor expressed on neutrophils and monocytes. TREM-1 acts to amplify inflammation and serves as a critical mediator of inflammatory response in the context of sepsis. Blocking of TREM-1 can protect against sepsis in mice. This study was designed to investigate whether TREM-1 genomic variations were associated with the prognosis of sepsis. We sequenced 30 sepsis patients with TREM-1 gene of four exons by PCR sequencing. When analyzing the results of sequencing, we found two gene polymorphisms located in exon-2 and exon-4, respectively. Compare with the NCBI dbSNP and Hapmap database, one polymorphisms located in exon-2 is non-synonymous variation rs2234237(Ser25Thr), the other one located in exon-4 is synonymous variation rs2234246. Two common polymorphisms (rs2234237,rs2234246) within the TREM-1 gene were detected in 80 patients with severe sepsis and in 80 healthy control subjects. This study was explored that whether or not polymorphisms detected within the TREM-1 gene may play a major role in the predisposition to prognosis of sepsis in a Chinese Han cohort.

Condition or disease

Study Type : Observational
Actual Enrollment : 160 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: Association Between TREM-1 Gene Polymorphisms and Prognosis in Sepsis Patient
Study Start Date : May 2010
Actual Primary Completion Date : October 2011
Actual Study Completion Date : October 2011

Resource links provided by the National Library of Medicine

SIRS plus inflammation
normal person under medical examination

Primary Outcome Measures :
  1. Patients Outcome [ Time Frame: 28 days ]
    The survival time of patients more than 28days is defined as survival. The survival time of patients less than 28days is defined as death

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
All subjects were selected from among inpatients who were hospitalized between September 2009 and October 2011 in the Respiratory ICU, Surgical ICU, and Emergency ICU, Chinese People's Liberation Army (CPLA) General Hospital.

Inclusion Criteria:

  • Sepsis met the criteria recommended by 1991 ACCP/SCCM Joint Meeting and by the diagnostic criteria developed at the 2001 International Sepsis Definition Conference.

Exclusion Criteria:

  • (1) younger than 18 years of age; (2) acquired immunodeficiency syndrome; (3) reduced polymorphonuclear granulocyte counts (< 500 μL-1); (4) died within 24h after admission into the ICU, or refused to participate in the study, or declined treatment during the period of observation.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01490424

China, Beijing
Chinese PLA General Hospital
Beijing, Beijing, China, 100853
Sponsors and Collaborators
Chinese PLA General Hospital
Study Director: Lixin Xie, MD Respiratory Disease Department of chinese PLA General Hospital

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT01490424     History of Changes
Other Study ID Numbers: 20111013-009(2)
2009BAI86B03 ( Other Grant/Funding Number: Chinese National Science & Technology Pillar Program )
First Posted: December 13, 2011    Key Record Dates
Last Update Posted: December 13, 2011
Last Verified: December 2011

Keywords provided by Chinese PLA General Hospital:
control(normal person)

Additional relevant MeSH terms:
Systemic Inflammatory Response Syndrome
Pathologic Processes