Gestational Diabetes Mellitus and Cardiometabolic Syndrome in Offspring (DG3)
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|ClinicalTrials.gov Identifier: NCT01490372|
Recruitment Status : Completed
First Posted : December 13, 2011
Last Update Posted : December 23, 2016
Gestational Diabetes Mellitus (GDM) has long been known as leading to macrosomias, neonatal hypoglycemias and other complications which are treatable and preventable. Nowadays, GDM is recognized as an entity with long-term serious sequels to the mother (GDM is considered a forerunner of type 2 diabetes) and her offspring. Indeed, according to the programming hypothesis, GDM sets the stage for metabolic syndrome, obesity, type 2 diabetes and hypertension. However, these cross-sectional studies failed to control for maternal disease history and genetic background although heredity is a major epidemiology risk factor of type 2 diabetes. Also, studies usually refer to traditional markers such as BMI, blood pressure, lipids profile and oral glucose tolerance test (OGTT); none explored inflammatory biomarkers and adipokines in-depth, despite the possible link between their presence and the development of metabolic and cardiovascular diseases in GDM offsprings.
Exclusion of genetic confounding factors will help establish the role of GDM as an independent marker of cardiometabolic risk in GDM offspring. It is highly relevant to identify GDM as a risk factor for cardiometabolic diseases, given the worldwide obesity epidemic, the alarming prevalence increase of GDM and its serious sequels to both mother and offspring.
|Condition or disease|
|Gestational Diabetes Mellitus|
|Study Type :||Observational|
|Actual Enrollment :||41 participants|
|Observational Model:||Case Control|
|Official Title:||Is Gestational Diabetes Mellitus (GDM) an Independent Risk Factor for Cardiometabolic Syndrome in Offspring?|
|Study Start Date :||August 2011|
|Primary Completion Date :||February 2013|
|Study Completion Date :||May 2013|
Children born from gestational diabetes mellitus pregnancy
Children born from a normal pregnancy
- Metabolic syndrome [ Time Frame: 4 to 12 years after birth. ]Prevalence of metabolic syndrome
- Inflammatory markers [ Time Frame: Assessed only once 4 to 12 years after birth ]4 to 12 years after birth.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01490372
|Centre de recherche clinique Étienne-Le Bel du CHUS|
|Sherbrooke, Quebec, Canada, J1H 5N4|
|Principal Investigator:||Jean-Luc Ardilouze, MD, PhD||Université de Sherbrooke|