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Inhibitory Receptors in Eosinophils of Atopic Subjects

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified April 2012 by Meir Medical Center.
Recruitment status was:  Recruiting
Information provided by (Responsible Party):
Meir Medical Center Identifier:
First received: December 7, 2011
Last updated: March 3, 2013
Last verified: April 2012
The purpose of this study is to analyze the expression and activity of inhibitory molecules on eosinophils obtained from allergic subjects.

Atopy Atopic Dermatitis Asthma Allergic Rhinitis Food Allergy

Study Type: Observational
Study Design: Observational Model: Case Control
Official Title: Characterization of the Expression and Activity of Inhibitory Receptors Such as CLM-1 in Eosinophils of Atopic Subjects

Resource links provided by NLM:

Further study details as provided by Meir Medical Center:

Primary Outcome Measures:
  • Expression of surface molecules on eosinophils as assessed by flow cytometry [ Time Frame: December 2013 ]
    Blood samples from donors will be stained and evaluated by flow cytomtery

Biospecimen Retention:   Samples With DNA
whole blood

Estimated Enrollment: 40
Study Start Date: January 2012
Estimated Study Completion Date: December 2013
Estimated Primary Completion Date: December 2013 (Final data collection date for primary outcome measure)
atopic subjects
Patients with one atopic disease or more (atopic dermatitis,rhinitis, asthma, food allergy)
non-atopic subjects
Control group without atopic diseases.


Ages Eligible for Study:   20 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
allergy clinic

Inclusion Criteria:

  • age 20-60 years
  • a physician-diagnosed atopic disease

Exclusion Criteria:

  • atopic disease not active
  • steroid treatment
  • active non-atopic inflammatory disease, including infections
  • pregnancy
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01489293

Contact: Alon Y Hershko, MD PhD 972-50-207-6448

Meir Medical Center. Unit of Allergy and Clinical Immunology Recruiting
Kfar Saba, Israel
Principal Investigator: Alon Y Hershko, MD, PhD         
Sponsors and Collaborators
Meir Medical Center
Principal Investigator: Alon Y Hershko, MD, PhD Meir Medical Center
  More Information

Responsible Party: Meir Medical Center Identifier: NCT01489293     History of Changes
Other Study ID Numbers: MMC110053CTIL
Study First Received: December 7, 2011
Last Updated: March 3, 2013

Additional relevant MeSH terms:
Rhinitis, Allergic
Dermatitis, Atopic
Food Hypersensitivity
Nose Diseases
Respiratory Tract Diseases
Respiratory Tract Infections
Otorhinolaryngologic Diseases
Skin Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Immune System Diseases
Skin Diseases, Genetic
Genetic Diseases, Inborn
Skin Diseases, Eczematous processed this record on July 27, 2017