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Use of EtCO2 as a PaCO2 Predictor Under Non Invasive Ventilation (NIV) in Cases of Acute Hypercapnic Respiratory Failure

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ClinicalTrials.gov Identifier: NCT01489150
Recruitment Status : Completed
First Posted : December 9, 2011
Last Update Posted : May 16, 2013
Sponsor:
Information provided by (Responsible Party):
Prof. Philippe Jolliet, University of Lausanne Hospitals

Study Description
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Brief Summary:
In patients treated by Non invasive ventilation (NIV) due to acute hypercapnic respiratory failure, the interest of using the End-tidal Co2 measurement device "Capnostream" to evaluate PaCo2 and PaCo2 variations over time will be evaluated. Measurements will be done under normal expiration and under prolonged active and passive expiration maneuvers.

Condition or disease
Hypercapnic Respiratory Failure

Study Design
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Study Type : Observational
Actual Enrollment : 11 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Use of EtCO2 and Prolonged Expiratory Maneuvers as a PaCO2 Predictor in Cases of Acute Hypercapnic Respiratory Failure
Study Start Date : December 2011
Actual Primary Completion Date : April 2012
Actual Study Completion Date : December 2012

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Groups and Cohorts
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Outcome Measures
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Primary Outcome Measures :
  1. Comparison between EtCO2,PaCO2 and PaCO2 variation under NIV during both spontaneous expiration and prolonged expiration [ Time Frame: Sixty minutes ]
    Comparison between EtCO2,PaCO2 and PaCO2 variation under NIV during both spontaneous expiration and prolonged expiration


Eligibility Criteria
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Intensive care unit patients equipped with arterial line requiring non invasive ventilation because of acute hypercapnic respiratory failure
Criteria

Inclusion Criteria:

  • ICU patient equipped with arterial line
  • NIV requirement
  • Hypercapnia: PaCO2 > 45mmhg

Exclusion Criteria:

  • Severe hemodynamic instability
  • Severe psychiatric disorders
  • nasal lesions
  • denied consent
Contacts and Locations
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

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To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01489150


Locations
Switzerland
Intensive care and burn unit, University Hospital of Lausanne
Lausanne, Switzerland, 1011
Sponsors and Collaborators
University of Lausanne Hospitals
Investigators
Principal Investigator: Philippe Jolliet, Professor University of Lausanne Hospitals
More Information
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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Responsible Party: Prof. Philippe Jolliet, Principal investigator, University of Lausanne Hospitals
ClinicalTrials.gov Identifier: NCT01489150     History of Changes
Other Study ID Numbers: EtCO2-NIV
First Posted: December 9, 2011    Key Record Dates
Last Update Posted: May 16, 2013
Last Verified: May 2013

Keywords provided by Prof. Philippe Jolliet, University of Lausanne Hospitals:
Acute respiratory failure
Hypercapnia
Non invasive ventilation
End-tidal CO2

Additional relevant MeSH terms:
Respiratory Insufficiency
Hypercapnia
Respiration Disorders
 Respiratory Tract Diseases
Signs and Symptoms, Respiratory
Signs and Symptoms