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Presence of Minor Anti Phospholipid Antibodies in Blood Samples of Ischemic Stroke Patients and Healthy Controls

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified December 2011 by Meir Medical Center.
Recruitment status was:  Not yet recruiting
Sheba Medical Center
Information provided by (Responsible Party):
Meir Medical Center Identifier:
First received: December 5, 2011
Last updated: December 6, 2011
Last verified: December 2011

The investigators expect to find higher levels of both classical and minor antiphospholipid (APL) antibodies among the stroke cases. Furthermore, the investigators expect to find not only classical APLA but also minor antibodies.

The investigators believe that minor antibodies have a major role in the hypercoagulability state.

Ischemic Stroke

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Presence of Minor Anti Phospholipid Antibodies in Blood Samples of Ischemic Stroke Patients and Healthy Controls.

Further study details as provided by Meir Medical Center:

Biospecimen Retention:   Samples Without DNA
Serum samples of Stroke patients withdrawned within 36 hrs since stroke evoked. Healthy controls

Estimated Enrollment: 207
Study Start Date: December 2011
Estimated Study Completion Date: September 2012
Estimated Primary Completion Date: March 2012 (Final data collection date for primary outcome measure)
Stroke patients
healthy controls


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
on a bank of 207 stroke patients serum samples, and also on 40 healthy controls. The samples were collected during the acute phase of the ischemic event.

Inclusion Criteria:

  • stroke diagnosis
  • blood sampling within 36hrs from the event
  • written agreement

Exclusion Criteria:

  • a stroke, MI or major operation prior to the current stroke
  • hypercoagulable state known in this patient
  • a severe chronic disease known at the time of the stroke
  • an infection on arrival (based on anamnesis, physical exam and lab tests)
  • thrombolytic treatment
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01487746

Contact: Yair Levy, Prof. 0533671735,
Contact: Narin N Carmel, B.Sc 0547691482

Meir health center Not yet recruiting
Kfar-saba, Israel
Sponsors and Collaborators
Meir Medical Center
Sheba Medical Center
  More Information

Responsible Party: Meir Medical Center Identifier: NCT01487746     History of Changes
Other Study ID Numbers: 0125-11-MMC
Study First Received: December 5, 2011
Last Updated: December 6, 2011

Keywords provided by Meir Medical Center:
minor anti body
major anti body
APLA antibodies in Serum

Additional relevant MeSH terms:
Cerebral Infarction
Cerebrovascular Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Vascular Diseases
Cardiovascular Diseases
Pathologic Processes
Brain Infarction
Brain Ischemia
Antibodies, Antiphospholipid
Immunologic Factors
Physiological Effects of Drugs processed this record on August 16, 2017