Respiratory Viral Infection in Nursing Home Slovenia
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|ClinicalTrials.gov Identifier: NCT01486160|
Recruitment Status : Completed
First Posted : December 6, 2011
Last Update Posted : November 30, 2012
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This study will be conducted in a 208-bed nursing home in Maribor. The investigators will observe a group of a 100 nursing-home residents and 50 health care workers- employees in the nursing home- in a six months period.Influenza vaccination status will be recorded in all participants at the beginning.
At the beginning and at the end of the study the blood samples for vitamin D concentration determination and nasopharyngeal swabs for molecular detection of respiratory viruses will taken in all of the participants.
The study will observe number of viral respiratory tract infection in participants and identify the viral etiology of infections during 6 months observational period.Nasopharyngeal swab and blood sample will be taken in each of the participant who will suffer an acute respiratory tract infection (upper or lower respiratory tract infection) and viral agents of respiratory tract diseases will be searched for. The investigators will try to detect different viral agents of respiratory tract infection: human rhinoviruses, enteroviruses, influenza A, B, parainfluenza 1-4, respiratory syncytial virus, human coronaviruses, human metapneumovirus, adenoviruses and human bocavirus with newer molecular methods (real-time polymerase chain reaction, real-time reverse transcriptase polymerase chain reaction) in nasopharyngeal swab and in blood sample of the participants.
During the study period the investigators will monitor the daily number of visitors (adults, preschool children and pupils) in each nursing home room. The epidemiological aspect of respiratory viral infection will be assessed.
Our study hypothesis is that lower respiratory tract infections in elderly can be caused by viruses other than influenza.
The investigators would like to know if hypovitaminosis D is a risk factor for respiratory tract infections in nursing home residents and employees.
The investigators would also like to know if the number of respiratory tract infections in elderly correlates with the number of visitors in nursing home, small children in particular.
|Condition or disease|
|Acute Viral Respiratory Tract Diseases|
|Study Type :||Observational|
|Actual Enrollment :||132 participants|
|Official Title:||Etiology, Frequency and Epidemiology of Respiratory Viral Infection in Nursing Home Residents|
|Study Start Date :||December 2011|
|Actual Primary Completion Date :||May 2012|
|Actual Study Completion Date :||November 2012|
nursing home residents
participants in this group are nursing home residents
Nursing home employees
Participants in this group are health care workers, employees at the nursing home
- Number of viral respiratory tract infection in participants according to etiology [ Time Frame: 6 months ]Number of participants with upper and lower respiratory tract infection will be detected and etiology of viral infection will be identified
- Serum vitamine D concentration in participants [ Time Frame: 6 months ]Serum concentration of vitamine D will be measured retrospectively from the blood samples taken at the beginning of the study and correlation between vitamine D concentration and the frequency of respiratory tract infection in participants will be made
- Daily number of visitors in nursing home in correlation with the number of respiratory tract infection in residents [ Time Frame: 6 months ]Daily number of visitors in each nursing home room will be counted and correlate with the number of respiratory tract infection in participants.
Biospecimen Retention: Samples With DNA
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|Ages Eligible for Study:||18 Years and older (Adult, Older Adult)|
|Sexes Eligible for Study:||All|
|Accepts Healthy Volunteers:||Yes|
|Sampling Method:||Non-Probability Sample|
- resident of the nursing home or employee ni the nursing home
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01486160
|Nursing home Tezno|
|Maribor, Slovenia, SI-2000|
|Principal Investigator:||Nina Gorisek Miksic, MD, M.sc||University Medical Centre Maribor|
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
|Responsible Party:||Nina Gorisek Miksic, Nina Gorisek Miksic, MD, M.Sc, infectologist, University Maribor|
|Other Study ID Numbers:||
|First Posted:||December 6, 2011 Key Record Dates|
|Last Update Posted:||November 30, 2012|
|Last Verified:||November 2012|
Respiratory Tract Diseases