Goal Directed Hemodynamic Management and Renal Outcome After Renal Transplant Surgery (IROR)
This study is designed to compare the incidence of delayed graft function in patients following renal transplant surgery with different perioperative hemodynamic managements: a goal directed hemodynamic management group (using PiCCO) and a control group.
|Study Design:||Time Perspective: Prospective|
|Official Title:||Can Goal Directed Hemodynamic Management Improve Renal Outcome After Renal Transplant Surgery?|
- delayed graft function [ Time Frame: Start of anesthesia until day 7 after the operation ] [ Designated as safety issue: No ]
|Study Start Date:||October 2011|
|Estimated Study Completion Date:||October 2015|
Group P: Fluid Management according to measurements with PiCCO®
Device: PiCCO® Monitoring
Fluid and vasopressor management according to PiCCO measurements
Group C: Conventional fluid management
Volume assessment and management during renal transplantation is one of the most challenging problems the anesthetist has to deal with. It seems sensible that individualized volume management and hydration therapy during the operation and during the stay at the intensive care unit could improve perfusion of the transplanted organ resulting in a better transplant function. Aim of this study is to investigate the impact of a goal directed hemodynamic management on incidence of delayed graft function (DGF) after renal transplant surgery.
Therefore patients will be randomized in one of two groups, the PiCCO group with goal directed hemodynamic management during operation and during the ICU-stay and the control group with hemodynamic management performed according to heart rate, blood pressure and central venous pressure.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01485432
|Contact: Bettina Jungwirth, MD||+49 89 4140 ext email@example.com|
|Klinik für Anaesthesiologie, Klinikum rechts der Isar der Technischen Universität München||Recruiting|
|Munic, Bavaria, Germany, 81675|
|Contact: Bettina Jungwirth, MD +49 89 4140 ext 4291 firstname.lastname@example.org|
|Principal Investigator: Bettina Jungwirth, MD|
|Sub-Investigator: Manfred Blobner, MD|
|Sub-Investigator: Barbara Kapfer, MD|
|Sub-Investigator: Sebastian Schmid, MD|
|Principal Investigator:||Bettina Jungwirth, MD||Klinik für Anaesthesiologie, Klinikum rechts der Isar der Technischen Universität München, Ismaninger Str. 22, 81675 München|