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Treatments of Acquired Apraxia of Speech (Apraxia)

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ClinicalTrials.gov Identifier: NCT01483807
Recruitment Status : Active, not recruiting
First Posted : December 1, 2011
Last Update Posted : February 5, 2018
Sponsor:
Information provided by (Responsible Party):
VA Office of Research and Development

Brief Summary:
This study is designed to examine the effects of speech therapy on ability to produce speech sounds in persons with acquired apraxia of speech.

Condition or disease Intervention/treatment Phase
Aphasia Apraxia of Speech Stroke Behavioral: SPT - Blocked Behavioral: SPT - Random Not Applicable

Detailed Description:
This study is designed to investigate the effects of Sound Production Treatment (SPT; a treatment for acquired apraxia of speech) on sound production accuracy in persons with chronic apraxia of speech (AOS). Organization of practice (blocked practice or randomized practice) will be manipulated in an effort to determine the most efficacious application of SPT. A combination of group and single-subject experimental designs will be completed with 24 speakers with AOS (2 groups of 12 participants).

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 24 participants
Allocation: Non-Randomized
Intervention Model: Crossover Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Treatments of Acquired Apraxia of Speech
Actual Study Start Date : August 1, 2011
Actual Primary Completion Date : January 31, 2017
Estimated Study Completion Date : June 30, 2018

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arm Intervention/treatment
Experimental: Arm 1 - Blocked Practice
Sound Production Treatment - Blocked: Sound Production Treatment was delivered using blocking of treatment stimuli = SPT- Blocked (intervention). Treatment stimuli representing two different sound targets were presented during treatment/practice with all stimuli for each target being grouped together. Treatment sessions were 50-60 minutes long. Treatment was administered three times per week for a total of 20 sessions, spanning approximately 7 weeks.
Behavioral: SPT - Blocked
A treatment for acquired apraxia of speech. Combines therapist modeling, simultaneous production, articulatory instruction, feedback and repeated practice
Experimental: Arm 2 - Randomized Practice
Sound Production Treatment - Random: Sound Production Treatment was delivered using randomization of treatment stimuli = SPT- Random (intervention). Treatment stimuli representing two different sound targets were presented during treatment/practice with stimuli for both targets being intermingled in a non predictable order. Treatment sesTreatment was administered three times per week for a total of 20 sessions, spanning approximately 7 weeks.
Behavioral: SPT - Random
A treatment for acquired apraxia of speech. Combines therapist modeling, simultaneous production, articulatory instruction, feedback and repeated practice - stimuli are practiced in non predictable order



Primary Outcome Measures :
  1. speech production [ Time Frame: Pre treatment (2-3 week period preceding the start of treatment) , Interim treatment (after 20 treatment session - approximately 7 weeks after the start of treatment), and Post treatment (after another 20 treatment sessions - approximately 15 weeks) ]
    accuracy of articulation



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Ages Eligible for Study:   21 Years to 85 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Must have acquired apraxia of speech that occurred following a stroke or other brain injury.
  • Must be at least 6 months post-onset of brain injury.
  • May have aphasia.

Exclusion Criteria:

  • History of drug or alcohol abuse.
  • History of mental illness.
  • Neurological condition other than that which resulted in apraxia of speech.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01483807


Locations
United States, Utah
VA Salt Lake City Health Care System, Salt Lake City, UT
Salt Lake City, Utah, United States, 84148
Sponsors and Collaborators
VA Office of Research and Development
Investigators
Principal Investigator: Julie L Wambaugh, PhD VA Salt Lake City Health Care System, Salt Lake City, UT

Publications of Results:

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: VA Office of Research and Development
ClinicalTrials.gov Identifier: NCT01483807     History of Changes
Other Study ID Numbers: C7419-R
First Posted: December 1, 2011    Key Record Dates
Last Update Posted: February 5, 2018
Last Verified: February 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided

Studies a U.S. FDA-regulated Drug Product: No
Studies a U.S. FDA-regulated Device Product: No
Product Manufactured in and Exported from the U.S.: No

Keywords provided by VA Office of Research and Development:
speech
speech therapy
apraxia of speech

Additional relevant MeSH terms:
Aphasia
Apraxias
Speech Disorders
Language Disorders
Communication Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Psychomotor Disorders