Vascular Occlusion and Rheumatoid Arthritis

This study is currently recruiting participants. (see Contacts and Locations)
Verified February 2014 by University of Sao Paulo
Information provided by (Responsible Party):
Bruno Gualano, University of Sao Paulo Identifier:
First received: November 29, 2011
Last updated: February 27, 2014
Last verified: February 2014
Resistance exercise plus vascular occlusion may induce greater improvements in strength and muscle mass resistance training alone. The investigators speculate this training strategy could be beneficial in patients with rheumatoid arthritis.

Condition Intervention
Rheumatoid Arthritis
Other: vascular occlusion with exercise trainig
Other: high intensity resistance training

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Effects of Strength Training With Vascular Occlusion in Patients With Rheumatoid Arthritis: A Randomized Clinical Trial

Resource links provided by NLM:

Further study details as provided by University of Sao Paulo:

Primary Outcome Measures:
  • muscle strength [ Time Frame: twelve weeks ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • quality of life [ Time Frame: twelve weeks ] [ Designated as safety issue: No ]

Estimated Enrollment: 30
Study Start Date: November 2011
Estimated Study Completion Date: November 2015
Estimated Primary Completion Date: November 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: low intensity with vascular occlusion Other: vascular occlusion with exercise trainig
twelve weeks of resistance training with vascular occlusion twice a week
Experimental: high intensity resistance training Other: high intensity resistance training
twelve weeks of resistance training twice a week
No Intervention: no exercise training


Ages Eligible for Study:   30 Years to 70 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • female with rheumatoid arthritis
  • Disease activity scores > 2.6
  • use of anti-TNF-alpha drugs for at least 8 weeks

Exclusion Criteria:

  • BMD < 20 kg/m2
  • fibromyalgia
  • cardiovascular disease
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01483157

University of Sao Paulo - School of Medicine - Clinical Hospital Recruiting
Sao Paulo, Brazil, 05403-010
Contact: Reynaldo Costa Rodrigues, PhD Student    55 11 26618022   
Principal Investigator: Ana Lucia Sa Pinto, PhD         
Sub-Investigator: Lissiane Noronha Guedes, MD         
Sub-Investigator: Bruno Gualano, PhD         
Sponsors and Collaborators
University of Sao Paulo
  More Information

No publications provided

Responsible Party: Bruno Gualano, Professor, University of Sao Paulo Identifier: NCT01483157     History of Changes
Other Study ID Numbers: vascular occlusion and RA
Study First Received: November 29, 2011
Last Updated: February 27, 2014
Health Authority: Brazil: National Committee of Ethics in Research

Additional relevant MeSH terms:
Arthritis, Rheumatoid
Autoimmune Diseases
Connective Tissue Diseases
Immune System Diseases
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases processed this record on November 25, 2015