Role of Polymorphisms in the Dectin-1 Gene in Determining the Risk of Candida Colonization and Infection in Critically Ill Patients (Dectin-1)
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ClinicalTrials.gov Identifier: NCT01482988
Verified November 2011 by Matt P Wise, Cardiff and Vale University Health Board. Recruitment status was: Not yet recruiting
: December 1, 2011
Last Update Posted
: December 1, 2011
Cardiff and Vale University Health Board
Information provided by (Responsible Party):
Matt P Wise, Cardiff and Vale University Health Board
The principal aim of this study is to establish if a polymorphism in a gene important for innate immunity to fungi represents a significant risk factor for the development of Candida colonisation and subsequent invasive candidosis in critically ill patients. Incorporation of a screening programme onto a risk-based algorithm for critical care patients would allow more effective targeting of molecular diagnostic tests, anti-fungal prophylaxis and targeted treatment. Sequential critical care patients will be screened for gene polymorphisms and undergo regular screening for Candida colonization.
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Critical care patients predicted to stay more than 72 hours
Patients aged > 18 years
Patients with anticipated or actual critical care unit stay > 72 hours
Consent or assent (if patient lacks capacity) obtained
Age < 18 years
Length of predicted stay on critical care < 72 hours consent or assent not obtained