Genome-wide Association Study to Predict Treatment Response for Molecular Targeted Therapy in Hepatocellular Carcinoma and Renal Cell Carcinoma
All Hepatocellular carcinoma and Renal cell carcinoma patients who receive molecular targeted therapy will be candidates for the study.
No additional treatment or intervention will be conducted except for blood sampling that will be limited to one time only.
Blood samples (10 cc in volume) will be collected from all study participants once they provided written informed consent form. DNA will be extracted from peripheral blood samples using DNA isolation kit.
Renal Cell Carcinoma
|Study Design:||Observational Model: Cohort
Time Perspective: Retrospective
|Official Title:||Genome-wide Association Study to Predict Treatment Response for Molecular Targeted Therapy in Hepatocellular Carcinoma and Renal Cell Carcinoma|
- Genotypes [ Time Frame: 36months ] [ Designated as safety issue: No ]
To define genotypes of HCC and RCC patients who will likely to response to molecular targeted therapy.
To define genotypes associated with adverse events from molecular targeted.
To identify genotypes which will predict survival or disease-free survival following molecular targeted therapy.
|Study Start Date:||August 2008|
|Study Completion Date:||October 2013|
|Primary Completion Date:||September 2013 (Final data collection date for primary outcome measure)|
|Renal cell carcinoma|
|Hepatocellular carcinoma patients|
Please refer to this study by its ClinicalTrials.gov identifier: NCT01482520
|Korea, Republic of|
|Samsung Medical Center|
|Seoul, Korea, Republic of|