Neurocognitive Study for the Aging-a Longitudinal Study With a Greek Cypriot Cohort (NEUROAGE)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT01481246|
Recruitment Status : Recruiting
First Posted : November 29, 2011
Last Update Posted : April 29, 2022
|Condition or disease||Intervention/treatment|
|Aging Memory Impairment Cognitive Decline Mild Cognitive Disorder||Behavioral: Categorization training Behavioral: Psychosocial and Psychoeducational Group training|
Given the fact that older adults are expected to live longer while maintaining their social and professional activities, the development of effective cognitive retraining methodologies designed to maximize independence has been of interest. In addition to changes caused by the normal aging process, older adults over 65 are at a high risk for developing dementia. About 8-12% of the older adult population will demonstrate a pre-dementia syndrome referred to as Mild Cognitive Impairment (MCI) which is considered a prodrome to dementia. Consequently, it is important to identify variables that contribute to the development of MCI as well as neurocognitive therapy approaches to help patients improve their level of functioning.
Categorization is one of the most fundamental cognitive processes. The ability to divide the world into discrete categories is a rudimentary process beginning early in life and continues to be developed and refined across the lifespan. This underlying process is crucial to a variety of neurocognitive abilities including attention and memory and can influence vocational and educational reintegration. Normal aging results in categorization deficits which in turn can interfere with the individual's ability to attend, remember, and organize information. This difficulty could hamper activities of daily living, social participation, and independence. This project implements an innovative treatment program based on current theoretical models of human cognition designed to improve neurocognitive abilities.
One of the objectives of the project is to provide evidence on the effectiveness of a systematic and hierarchical neurocognitive therapy method, the Categorization Program (CP) in adults with MCI and in normal older adults. It is hypothesized that the CP will be an effective treatment approach to improve categorization abilities in both groups of subjects. In addition, since 2020, we have been implementing a group intervention program as part of our recent funding to investigate its feasibility in healthy older adults and in adults with MCI.
The following activities have been taking place:
- Initially, a population-based sample of 500 older adults was tested using a battery of neuropsychological measures. Normal older adults are reassessed every two years. Currently, more than 800 healthy adults have been recruited in this project.
- Second, normal OA and adults with MCI have been randomly assigned into either the treated or untreated groups. The treated groups receive the CP training in order to test its effectiveness.
- Third, the long term effects of cognitive retraining is being assessed.
- Finally, the project examines the relationship between the categorization tasks, neuropsychological performance, functional outcome measures, and subject characteristics including health indices, education, and biomarkers. Theoretical constructs such as Cognitive Reserve have been explored as part of this project.
The long-term objective of this research program is to determine variables that influence cognitive decline in older adults and develop effective neurocognitive therapy techniques.
|Study Type :||Observational|
|Estimated Enrollment :||1000 participants|
|Official Title:||The Neurocognitive Study for the Aging|
|Study Start Date :||July 2009|
|Estimated Primary Completion Date :||March 2023|
|Estimated Study Completion Date :||March 2023|
Normal Aging/Cognitive Decline
Health adults as well as adults with MCI and early stage AD are being recruited in the study
Behavioral: Categorization training
Behavioral intervention consisting of cognitive training exercises to improve categorization performance
Behavioral: Psychosocial and Psychoeducational Group training
Group treatment with a focus on psychosocial and psychoeducational intervention in healthy adults and in adults with cognitive decline. Ten week cycle, 2 hours per week group intervention study.
- Neuropsychological Tests [ Time Frame: on going ]a variety of cognitive tests as well as psychosocial measures are used in this project
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01481246
|Contact: Fofi Constantinidou, Ph.D.||email@example.com|
|University of Cyprus||Recruiting|
|Nicosia, Cyprus, 1678|
|Contact: Fofi Constantinidou, Ph.D. 35722894437 firstname.lastname@example.org|
|Principal Investigator: Fofi Constantinidou, Ph.D.|
|Principal Investigator:||Fofi Constantinidou, Ph.D.||University of Cyprus|