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Long-term Results Following Endoscopic Vein Harvesting in Coronary Artery Bypass Surgery

This study has been completed.
Aalborg University
Information provided by (Responsible Party):
Jan Jesper Andreasen, MD, PhD, Aalborg Universitetshospital Identifier:
First received: November 24, 2011
Last updated: April 13, 2015
Last verified: November 2011

Vena saphena magna is still frequently used as graft material in coronary artery bypass grating(CABG, and vein grafts can harvest with either the conventional open technique (Ovh = open vein harvesting), or with less invasive endoscopic techniques (EVH = Endoscopic vein harvesting). The endoscopic techniques have been shown to reduce the incidence of postoperative wound complications while patients are more satisfied with the cosmetic result of the operation on the leg.

Non-randomized studies have raised doubts about patency rates of the vein grafts following EVH compared to OVH, while other studies failed to detect any problems in relation to this. There are only very few data on long-term patency rates from randomized studies.

The purpose of this study is to investigate clinical outcome and patency rates of the vein grafts following either EVH and OVH in 132 patients who underwent CABG for 4-7 years ago as part of a randomized study investigation wound complications. A cost-effectiveness analysis will also be performed.

The hypothesis is: Patency rates following EVH are worse compared to OVH in CABG 4-7 years postoperatively.

Condition Intervention
Angina Pectoris Procedure: Surgery

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Endoscopic Versus Open Vein Harvest in Coronary Artery Bypass Grafting. Clinical and CT-angiographic Long-term Result From a Randomized Study.

Resource links provided by NLM:

Further study details as provided by Jan Jesper Andreasen, MD, PhD, Aalborg Universitetshospital:

Primary Outcome Measures:
  • Patency rates of vein grafts [ Time Frame: 5-7 years postoperatively ]

Secondary Outcome Measures:
  • recurrence of angina pectoris [ Time Frame: 5-7 years postoperatively ]

Enrollment: 132
Study Start Date: November 2011
Study Completion Date: January 2015
Primary Completion Date: December 2013 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Open vein harvest
Conventional open vein harvest from the lower leg
Procedure: Surgery
Endoscopic vein harvest
Endoscopic vein harvest from the calf
Procedure: Surgery

  Show Detailed Description


Ages Eligible for Study:   43 Years to 90 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
A total of 132 patients who underwent CABG 4-7 years ago. All patients participated in a randomized study focusing on wound complications from the leg following either open or endoscopic vein harvest.

Inclusion Criteria:

  • Patients who participated in the previous randomized study
  • Informed consent from the patient

Exclusion Criteria:

  • Survival until date of reexamination
  • No informed consent
  • CT scan of the heart will not be performed in patients with if: atrial fibrillation,p-creatinin >120 micromol/l, allergy to contrast, pregnancy, lactating.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01480726

Aalborg University Hospital
Aalborg, Denmark, 9100
Sponsors and Collaborators
Aalborg Universitetshospital
Aalborg University
Principal Investigator: Jan J. Andreasen, MD. PhD Aalborg Universitetshospital
  More Information

Responsible Party: Jan Jesper Andreasen, MD, PhD, Professor, MD, PhD, Aalborg Universitetshospital Identifier: NCT01480726     History of Changes
Other Study ID Numbers: N20110023
Study First Received: November 24, 2011
Last Updated: April 13, 2015

Additional relevant MeSH terms:
Angina Pectoris
Chest Pain
Neurologic Manifestations
Nervous System Diseases
Myocardial Ischemia
Heart Diseases
Cardiovascular Diseases
Vascular Diseases
Signs and Symptoms processed this record on July 21, 2017