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Effect of Body Composition and Metabolism on Oocyte Gene Expression

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ClinicalTrials.gov Identifier: NCT01480024
Recruitment Status : Active, not recruiting
First Posted : November 28, 2011
Last Update Posted : February 13, 2018
Sponsor:
Information provided by (Responsible Party):
Arkansas Children's Hospital Research Institute

Brief Summary:
The investigators will test the hypothesis that obese women have a unique oocyte gene expression profile that differs significantly from that of normal weight women.

Condition or disease
Healthy

Study Type : Observational
Estimated Enrollment : 70 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Effect of Body Composition and Metabolism on Oocyte Gene Expression
Study Start Date : April 2011
Estimated Primary Completion Date : December 2019
Estimated Study Completion Date : December 2019

Resource links provided by the National Library of Medicine

U.S. FDA Resources




Primary Outcome Measures :
  1. oocyte gene expression profile [ Time Frame: 1-2 weeks ]

Biospecimen Retention:   Samples With DNA
oocytes and follicular fluid


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 38 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
women of childbearing age undergoing fertility treatment
Criteria

Inclusion Criteria:

  • BMI < 25 (N=35) or BMI ≥ 30 (N=35)
  • Seeking fertility treatment at the Arkansas Fertility and Gynecology Associates Clinic
  • Assisted reproduction will include the oocyte retrieval technique
  • 18 to 38 years of age

Exclusion Criteria:

  • Any health condition or medication that may interfere with the study outcome as determined by the investigators

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01480024


Locations
United States, Arkansas
Arkansas Children's Nutrition Center
Little Rock, Arkansas, United States, 72202
Sponsors and Collaborators
Arkansas Children's Hospital Research Institute

Responsible Party: Arkansas Children's Hospital Research Institute
ClinicalTrials.gov Identifier: NCT01480024     History of Changes
Other Study ID Numbers: 131386
First Posted: November 28, 2011    Key Record Dates
Last Update Posted: February 13, 2018
Last Verified: February 2018

Keywords provided by Arkansas Children's Hospital Research Institute:
healthy women
oocytes
in vitro fertilization
pregnancy
childbearing-age