Difference of Plasma Orexin A Levels Between Elderly and Young Patients at Emergence
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT01478906|
Recruitment Status : Unknown
Verified May 2012 by Xijing Hospital.
Recruitment status was: Recruiting
First Posted : November 23, 2011
Last Update Posted : May 15, 2012
|Condition or disease|
BACKGROUND:A specific group of neurons in the brain produces hypocretin, also called orexin, a peptide which has been established as an important regulator of anesthesia and emergence in the latest few years. In the animal experiment,we found that the level of orexin A in aged rats was higher when compared with that of the young ones. Whereas the numbers of both the orexin receptor 1 and 2 in aged rats decreased. We wonder if there is a similar phenomenon in human beings which might account for the difference between the intervals of elderly and young patients recovering from anesthesia. This study aims to investigate difference of plasma orexin A levels between elderly patients and young at emergence from sevoflurane-fentanyl anesthesia.
DESIGNING:Forty patients with ASA physical status I or II scheduled for elective lumbar surgery under general anesthesia (lasting for 2h to 4h)were enrolled. Anesthesia was induced with propofol 1-1.5mg/kg and fentanyl 2-3μg/kg. Following muscle relaxation with iv rocuronium bromide 1mg/kg endotracheal intubation was performed. Anesthesia was maintained with sevoflurane(inhalational concentration: 0.8-1.5 MAC) fentanyl (total 6μg/kg) and target controlled infusion remifentanil (targeted concentration:2-7ng/ml ) along with an oxygen/air mixture (FiO2 = 0.5). Muscle relaxation was maintained with intermittent rocuronium. Inhalational concentration of sevoflurane and injected target concentration were titrated to maintain the bispectral index (BIS) between 45 and 65 during anesthesia. The end-tidal carbon dioxide level was maintained between 30 and 40mmHg by controlled mechanical ventilation. When the surgery was complicated we adjust the concentration sevoflurane to 0.8MAC of the patient and targeted concentration of remifentanil to 2ng/ml and then stop all anesthetics . Record time from stopping anesthetics to emergence. Arterial blood (2ml) was collected at the following time, such as before and 1h after induction of anesthesia, at emergence (1min after tracheal extubation) and half an hour after tracheal extubation. This was centrifuged at 3000 rpm for 15min at −4 ◦C in order to separate plasma then stored at −80 ◦C until assay for orexin A concentrations.
EXPECTED RESULTS:The plasma orexin A of group elderly will be higher with the emergence time longer than youth patients.
|Study Type :||Observational|
|Estimated Enrollment :||40 participants|
|Official Title:||To Investigate Difference of Plasma Orexin A Levels Between Elderly and Youth Patients at Emergence From Sevoflurane-fentanyl Anesthesia Undergoing Elective Lumbar Surgery|
|Study Start Date :||July 2011|
|Estimated Primary Completion Date :||June 2012|
|Estimated Study Completion Date :||September 2012|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01478906
|Contact: Hailong Dong, MD,PhDfirstname.lastname@example.org|
|Anesthesiology department of Xijing Hospital||Recruiting|
|Xi'an, Shaanxi, China, 710032|
|Contact: Zhihua Wang, postgraduate 86-2984775343 email@example.com|
|Principal Investigator: Hailong Dong, MD,PhD|
|Study Director:||Hailong Dong, MD,PhD||Xijing Hospital|