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Arthritis Research UK Gout Treatment Trial - Phase 2

This study has been completed.
Arthritis Research UK
Information provided by (Responsible Party):
University of Nottingham Identifier:
First received: November 14, 2011
Last updated: January 4, 2017
Last verified: January 2017
The purpose of this study is to determine in community-derived patients with gout the effectiveness, and cost effectiveness, of a nurse-led complex intervention that reflects recommended best practice (including patient information concerning gout, its prognosis and its non-pharmacological and drug options).

Condition Intervention
Gout Other: Nurse intervention Other: Standard care

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Arthritis Research UK Gout Treatment Trial. Phase 2: Two Year Randomised Controlled Trial of a Nurse Led Package of Care

Resource links provided by NLM:

Further study details as provided by University of Nottingham:

Primary Outcome Measures:
  • Reduction in serum uric acid levels [ Time Frame: 2 years ]

Secondary Outcome Measures:
  • Reduction in number of self reported acute attacks during year 2 [ Time Frame: 2 years ]
  • Improved Quality of Life scores at study end [ Time Frame: 2 years ]

Enrollment: 517
Study Start Date: March 2013
Study Completion Date: October 2016
Primary Completion Date: October 2016 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Nurse intervention
Nurse led package of care based on current recommended best practice.
Other: Nurse intervention
Complex package of care involving patient information and advice concerning lifestyle modification and recommended drug therapy.
Standard care
Continuing standard general practitioner led care
Other: Standard care
Continuing standard General Practitioner led care.


Ages Eligible for Study:   21 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Diagnosis of gout
  • At least one acute attack of gout within previous 12 months

Exclusion Criteria:

- Inability to give informed consent and known terminal or mental illness

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01477346

United Kingdom
Academic Rheumatology, University of Nottingham
Nottingham, United Kingdom, NG5 1PB
Sponsors and Collaborators
University of Nottingham
Arthritis Research UK
Principal Investigator: Michael Doherty, MA MD FRCP University of Nottingham
  More Information

Responsible Party: University of Nottingham Identifier: NCT01477346     History of Changes
Other Study ID Numbers: 11115
Study First Received: November 14, 2011
Last Updated: January 4, 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Additional relevant MeSH terms:
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases
Purine-Pyrimidine Metabolism, Inborn Errors
Metabolism, Inborn Errors
Genetic Diseases, Inborn
Metabolic Diseases processed this record on August 17, 2017