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Effects of Aerobic and Resistance Training on Accumulation of Old, Modified Proteins in Young and Older Adults

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ClinicalTrials.gov Identifier: NCT01477164
Recruitment Status : Completed
First Posted : November 22, 2011
Last Update Posted : August 8, 2017
Sponsor:
Information provided by (Responsible Party):
K. Sreekumaran Nair, Mayo Clinic

Brief Summary:

Muscle proteins accumulate damage during aging and leads to the loss of muscle mass and function in older people. Exercise can increase the making of new proteins and removal of older proteins, but it is not known if the effect changes with aging or type of exercise. The investigators will determine the ability for endurance, resistance, or a combination of exercise training to remove older-damaged proteins and make newer-functional muscle proteins in groups of younger and older people. The investigators will particularly study protein that are involved with energy production (mitochondrial proteins) and force production (contractile proteins).

Hypothesis 1: Older people will have greater accumulation of damaged proteins than younger people.

Hypothesis 2: Aerobic exercise will decrease the accumulation of damaged forms of contractile and mitochondrial proteins in younger and older people.

Hypothesis 3: Resistance exercise will decrease the accumulation of damaged forms of contractile proteins in younger and older people.


Condition or disease Intervention/treatment Phase
Sarcopenia Behavioral: High intensity aerobic exercise Behavioral: Resistance exercise training Behavioral: Combined Not Applicable

Detailed Description:
The loss of muscle mass and function with age leads to high social and economic costs. Lifestyle interventions that can help maintain muscle mass and function can be beneficial to improve health and decrease the costs associated with loss of independence in the elderly. Muscle proteins accumulate damage during aging, which is suggested to lead to loss of function. The biological processes that remove damaged proteins and synthesis new proteins appear to be decreased with aging. Exercise is known to increase the processes that remove older and synthesis newer muscle proteins and may be an effect lifestyle intervention to improve muscle quality and function. Additionally, specific types of proteins appear to decay with age including contractile and mitochondrial proteins. Different types of exercise training can increase the making of specific proteins. The investigators will examine the ability for aerobic and resistance training to increase the quality of mitochondrial and contractile proteins between younger and older people.

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 72 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Effects of Aerobic and Resistance Training on Accumulation of Old, Modified Proteins in Young and Older Adults
Study Start Date : November 2011
Actual Primary Completion Date : May 2016
Actual Study Completion Date : March 2017

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arm Intervention/treatment
Experimental: Aerobic Exercise Training
Participants will perform 12-weeks of high intensity aerobic training.
Behavioral: High intensity aerobic exercise
Participants will perform 12-weeks of high intensity aerobic training. Training will be 5-days per week. Three days (e.g. Monday, Wednesday and Friday) will include repeated bouts of cycling for 4-minutes at ~90% maximal effort followed by 3 minutes of active rest. The other two days (e.g. Tuesday and Thursday) will be treadmill exercise for 45 minutes at 70% of maximal effort.
Active Comparator: Combined
The combined group will have 12-weeks of no exercise followed by 12-weeks of combined aerobic and resistance exercise training. Assessments will be made at three time points: baseline, after 12-weeks of no training, and after 12-weeks of combined training.
Behavioral: Combined
The combined group will be assessed before and after 12 weeks of no exercise training, then again following 12 weeks of combined aerobic and resistance exercise training.
Experimental: Resistance Exercise Training
Participants will perform 12-weeks of resistance exercise training.
Behavioral: Resistance exercise training
Participants will perform 12-weeks of resistance exercise training. Training will be 5-days per week of daily sessions of 60 minutes that include resistance exercise for all major muscle groups.



Primary Outcome Measures :
  1. Skeletal muscle protein synthesis rate [ Time Frame: Approximately 14 weeks for the endurance or resistance training groups and approximately 28 weeks for the combined group ]
    The investigators will determine the rate of incorporation of stable isotope amino acid tracers in skeletal muscle proteins during several hours of rest. The measurement will be an average resting muscle protein synthesis rate (% new muscle protein per hour) and will be performed at baseline and following 12 weeks of exercise training.



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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy
  • 18 to 30 years or 65 to 80 years old
  • Male and female

Exclusion Criteria:

  • Regular exercise program
  • Smoking
  • Metabolic disease (diabetes, cardiovascular disease, cancer, thyroid disorders)
  • Pregnancy
  • Inability to exercise
  • Overweight or obesity
  • Drugs known to impair metabolic function (statin, beta-blocker, anti-inflammatory)
  • Allergies to lidocaine

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01477164


Locations
United States, Minnesota
Mayo Clinic
Rochester, Minnesota, United States, 55905
Sponsors and Collaborators
Mayo Clinic
Investigators
Principal Investigator: K. Sreekumaran Nair, M.D., Ph.D. Mayo Clinic

Responsible Party: K. Sreekumaran Nair, Principal Investigator, Mayo Clinic
ClinicalTrials.gov Identifier: NCT01477164     History of Changes
Other Study ID Numbers: 10-005853
First Posted: November 22, 2011    Key Record Dates
Last Update Posted: August 8, 2017
Last Verified: August 2017

Keywords provided by K. Sreekumaran Nair, Mayo Clinic:
Exercise
Aging
Sarcopenia
Muscle function

Additional relevant MeSH terms:
Sarcopenia
Muscular Atrophy
Neuromuscular Manifestations
Neurologic Manifestations
Nervous System Diseases
Atrophy
Pathological Conditions, Anatomical
Signs and Symptoms
Menthol
Antipruritics
Dermatologic Agents