Cerebral Blood Circulation in Patients With Posterior Fossa Brain Tumor
Recruitment status was: Not yet recruiting
The normal cerebral blood flow is guided by factors such as cerebral autoregulation (CA) and carbon dioxide reactivity (CO2R). Authors have demonstrated that CA and CO2R may be impaired in presence of intracranial tumors.Most studies pertaining to assessment of CA and CO2R in patients with brain tumors is limited to supratentorial tumors. Due to their anatomic location, posterior fossa tumors result in obstruction of ventricular outflow, produce hydrocephalus and features of raise intracranial pressure (ICP). It is possible that lesions in the posterior fossa may affect CA and CO2R. It should also be noted that posterior fossa surgeries are carried out in positions such as prone, lateral and sitting. Altered surgical positions themselves affect systemic hemodynamics which may influence cerebral blood flow; with presence of anesthetics further compromising the blood flow to the brain. Understanding the homeostatic mechanisms of CA and CO2R may help in deciding proper positioning of patients and maintenance of intraoperative hemodynamic.
The aim of this observational study was to evaluate CA and CO2R in patients with posterior fossa tumor prior to surgical decompression of the lesion.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Cerebral Autoregulation and Carbon Dioxide Reactivity in Patients With Posterior Fossa Tumor|
|Study Start Date:||July 2012|
Posterior fossa tumor
Patients with posterior fossa tumor scheduled for elective surgery will be enrolled in the study.
Transcranial Doppler will be used to assess the cerebral autoregulation and carbon dioxide reactivity of patients with posterior fossa tumor
Please refer to this study by its ClinicalTrials.gov identifier: NCT01476670
|All India Institute of Medical Sciences|
|New Delhi, Delhi, India, 110029|
|Principal Investigator:||Hemanshu Prabhakar, MD||All India Institute of Medical Sciences, New Delhi|