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Daily Activities Are Sufficient to Induce Dynamic Pulmonary Hyperinflation and Dyspnea in Chronic Obstructive Pulmonary Disease Patients (Hyperinflation)

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ClinicalTrials.gov Identifier: NCT01475812
Recruitment Status : Completed
First Posted : November 21, 2011
Last Update Posted : November 21, 2011
Information provided by (Responsible Party):

Study Description
Brief Summary:
Introduction: Chronic obstructive pulmonary disease is a condition characterized by airflow limitation usually progressive and associated with inflammatory response of lung noxious particles. During a physical activity chronic obstructive pulmonary disease patients may develop dynamic pulmonary hyperinflation, increased dyspnea perception and decreased activity performance. The investigators hypothesize that some specific activities of daily living induce dynamic pulmonary hyperinflation in COPD patients. Objective: To measure dynamic lung hyperinflation and its influence in dyspnea perception in moderate and severe chronic obstructive pulmonary disease patients after activities of daily living. Methods: The investigators measured inspiratory capacity, dyspnea sensation, peripheral oxygen saturation, heart rate and respiratory rate in 19 chronic obstructive pulmonary disease (COPD) patients. These measurements were taken at rest and after daily living activities (such as going up and down a set of stairs, going up and down a ramp and sweeping and mopping a room).

Condition or disease Intervention/treatment
Dynamic Lung Hyperinflation COPD Patients Activities of Daily Livin. Other: Hyperinflation and ADL

Study Design

Study Type : Observational
Actual Enrollment : 19 participants
Time Perspective: Cross-Sectional
Study Start Date : March 2007

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Groups and Cohorts

Group/Cohort Intervention/treatment
COPD hyperinflation Other: Hyperinflation and ADL
Assessment of dynamic pulmonary hyperinflation during activities of daily living in COPD patients.

Outcome Measures

Primary Outcome Measures :
  1. Inspiratory capacity variability within the accomplishment of activities of daily living in COPD patients. [ Time Frame: 3 months ]

Eligibility Criteria

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Ages Eligible for Study:   50 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
The investigators included 19 COPD patients (13 male) with moderate to very severe degree of airway obstruction, with a mean post bronchodilator forced expiratory volume in the first second (FEV1) of 48.7 ± 7.1% predicted and mean age of 64.1 ± 5.3.

Inclusion Criteria:

  • COPD patients diagnosed with moderate to very severe airway obstruction according to GOLD classification (9)
  • clinical stability with no clinical exacerbation during the previous 30 days prior to the beginning of the study and to sign an informed consent form

Exclusion Criteria:

  • Inability to perform the slow vital capacity maneuver
  • excessive perceived dyspnea during the test
  • arterial oxyhemoglobin saturation (SpO2) lower than 80% during activities and/or need of oxygen supplementation
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01475812

Federal University of São Paulo
São Paulo, São Paulo/SP, Brazil, 05414000
Sponsors and Collaborators
Federal University of São Paulo
More Information

Responsible Party: Antonio A.M. Castro, Dr., Federal University of São Paulo
ClinicalTrials.gov Identifier: NCT01475812     History of Changes
Other Study ID Numbers: 0353/03
First Posted: November 21, 2011    Key Record Dates
Last Update Posted: November 21, 2011
Last Verified: November 2011

Keywords provided by Antonio A.M. Castro, Federal University of São Paulo:
activities of daily living
pulmonary hyperinflation

Additional relevant MeSH terms:
Pulmonary Disease, Chronic Obstructive
Lung Diseases, Obstructive
Lung Diseases
Respiratory Tract Diseases