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Pregnancy Outcomes in Congenital Myasthenie Syndrome (POCoMS)

This study has been completed.
Assistance Publique - Hôpitaux de Paris
Information provided by (Responsible Party):
Laurent Servais, M.D., Institut de Myologie, France Identifier:
First received: November 16, 2011
Last updated: November 17, 2011
Last verified: November 2011
This is a retrospective study that follows the clinical evolution, the pregnancy and the post-partum perioad of female patients with Congenital Myasthenic Syndrome.

Congenital Myasthenic Syndrome

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Retrospective Study :Describe the Changes of the Disease in Many Cases Likely to Aggravate.

Resource links provided by NLM:

Further study details as provided by Laurent Servais, M.D., Institut de Myologie, France:

Enrollment: 25
Study Start Date: January 2010
Study Completion Date: October 2011
Primary Completion Date: January 2011 (Final data collection date for primary outcome measure)
Detailed Description:
The aim of this study is to better understand the action of hormonal factors that are presumably incriminated for the fluctuation of the disease. The investigators would also like to better adress the issues of women with Congenital Myasthenic Syndrome, who desire a pregnancy : the possibility of decompensation, the problems that can arise during the course of the childbearing, the risk of foetal malformations.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Women with Congenital Myasthenie Syndrome

Inclusion criteria:

  • Adult women
  • Congenital myastenic syndrome genetically confirmed or with clinical compatible and electrophysiological evidence
  • Written consent

Exclusion Criteria:

  • Neurological or general pathology occurs significantly with the initiation and conduct of a pregnancy.
  Contacts and Locations
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Please refer to this study by its identifier: NCT01474980

Sponsors and Collaborators
Institut de Myologie, France
Assistance Publique - Hôpitaux de Paris
Principal Investigator: Laurent SERVAIS, MD, PhD institut myologie
  More Information

Responsible Party: Laurent Servais, M.D., Laurent SERVAIS MD, PhD, Institut de Myologie, France Identifier: NCT01474980     History of Changes
Other Study ID Numbers: 2010-A00495-34
Study First Received: November 16, 2011
Last Updated: November 17, 2011

Keywords provided by Laurent Servais, M.D., Institut de Myologie, France:
Congenital Myasthenic Syndrome

Additional relevant MeSH terms:
Lambert-Eaton Myasthenic Syndrome
Myasthenic Syndromes, Congenital
Paraneoplastic Syndromes, Nervous System
Paraneoplastic Syndromes
Pathologic Processes
Nervous System Neoplasms
Neoplasms by Site
Autoimmune Diseases of the Nervous System
Nervous System Diseases
Neurodegenerative Diseases
Neuromuscular Junction Diseases
Neuromuscular Diseases
Autoimmune Diseases
Immune System Diseases
Genetic Diseases, Inborn processed this record on September 21, 2017