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Pregnancy Outcomes in Congenital Myasthenie Syndrome (POCoMS)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01474980
First Posted: November 18, 2011
Last Update Posted: November 18, 2011
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Assistance Publique - Hôpitaux de Paris
Information provided by (Responsible Party):
Laurent Servais, M.D., Institut de Myologie, France
  Purpose
This is a retrospective study that follows the clinical evolution, the pregnancy and the post-partum perioad of female patients with Congenital Myasthenic Syndrome.

Condition
Congenital Myasthenic Syndrome

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Retrospective Study :Describe the Changes of the Disease in Many Cases Likely to Aggravate.

Resource links provided by NLM:


Further study details as provided by Laurent Servais, M.D., Institut de Myologie, France:

Enrollment: 25
Study Start Date: January 2010
Study Completion Date: October 2011
Primary Completion Date: January 2011 (Final data collection date for primary outcome measure)
Detailed Description:
The aim of this study is to better understand the action of hormonal factors that are presumably incriminated for the fluctuation of the disease. The investigators would also like to better adress the issues of women with Congenital Myasthenic Syndrome, who desire a pregnancy : the possibility of decompensation, the problems that can arise during the course of the childbearing, the risk of foetal malformations.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Women with Congenital Myasthenie Syndrome
Criteria

Inclusion criteria:

  • Adult women
  • Congenital myastenic syndrome genetically confirmed or with clinical compatible and electrophysiological evidence
  • Written consent

Exclusion Criteria:

  • Neurological or general pathology occurs significantly with the initiation and conduct of a pregnancy.
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01474980


Sponsors and Collaborators
Institut de Myologie, France
Assistance Publique - Hôpitaux de Paris
Investigators
Principal Investigator: Laurent SERVAIS, MD, PhD institut myologie
  More Information

Responsible Party: Laurent Servais, M.D., Laurent SERVAIS MD, PhD, Institut de Myologie, France
ClinicalTrials.gov Identifier: NCT01474980     History of Changes
Other Study ID Numbers: 2010-A00495-34
First Submitted: November 16, 2011
First Posted: November 18, 2011
Last Update Posted: November 18, 2011
Last Verified: November 2011

Keywords provided by Laurent Servais, M.D., Institut de Myologie, France:
Congenital Myasthenic Syndrome
Pregnancy
Outcome

Additional relevant MeSH terms:
Syndrome
Lambert-Eaton Myasthenic Syndrome
Myasthenic Syndromes, Congenital
Disease
Pathologic Processes
Paraneoplastic Syndromes, Nervous System
Nervous System Neoplasms
Neoplasms by Site
Neoplasms
Paraneoplastic Syndromes
Autoimmune Diseases of the Nervous System
Nervous System Diseases
Neurodegenerative Diseases
Neuromuscular Junction Diseases
Neuromuscular Diseases
Autoimmune Diseases
Immune System Diseases
Genetic Diseases, Inborn