A Safer Pre-Natal Diagnosis Using Free DNA in Maternal Blood (IONA)
|Official Title:||A Safer Pre-Natal Diagnosis Using Free DNA in Maternal Blood|
- Validation of method of novel analysis for Aneuploidy [ Time Frame: 2013 Approx ] [ Designated as safety issue: No ]Analysis of maternal blood by a selective amplification of fetal DNA over maternal DNA within that sample. Patients to be followed up for 1 year.
- Optimization of existing methods for maximising ffDNA [ Time Frame: up to July 2019 ] [ Designated as safety issue: No ]Use of novel methods either in conjugation with existing methods or as a substitute for steps in existing methodologies- currently undergoing laboratory development that could increase the titre of fetal DNA within a given sample. Patients will be followed up for 1 year.
Biospecimen Retention: Samples With DNA
Maternal peripheral blood samples taken in EDTA with that required for existing analysis.
Approx 1ml of fluid from amniocentesis/chorionic villus sampling is taken additional. Patients will be followed up for 1 year after sample taken.
|Study Start Date:||April 2007|
|Estimated Study Completion Date:||July 2019|
|Estimated Primary Completion Date:||December 2018 (Final data collection date for primary outcome measure)|
T13, 18, 21 and other chromosomal abnormalities yet to be determined
Please refer to this study by its ClinicalTrials.gov identifier: NCT01472523
|Contact: Rosalyn Mazey, BSc(hons)||01616676865 ext firstname.lastname@example.org|
|Manchester, United Kingdom, M156SZ|
|Contact: Rosalyn Mazey, BSc(hons) 01616676865 ext 1037 email@example.com|
|Contact: William Denman, MBBS 0016177630620 firstname.lastname@example.org|
|Principal Investigator: Brenda Kelly, MBBS|
|Principal Investigator:||Brenda Kelly, MBBS||National Health Service, United Kingdom|