Effects of Pioglitazone in Hypertensive Patients

This study has been completed.
Information provided by (Responsible Party):
Kazuhide Ogino, Tottori University Hospital
ClinicalTrials.gov Identifier:
First received: July 21, 2011
Last updated: June 3, 2012
Last verified: June 2012
Insulin resistance is often complicated with hypertension. AGE and inflammation play important roles in insulin resistance. Some studies reported that pioglitazone, insulin sensitizer, is effective for patients with insulin resistance, however, the mechanisms are still unclear. The aim of this study to evaluate the effect of pioglitazone compared with glimepiride on AGE, inflammatory cytokines and cardiac markers (BNP and echo) in hypertensive patients during oral glucose tolerance test.

Condition Intervention Phase
Insulin Resistance
Drug: Pioglitazone
Phase 4

Study Type: Interventional
Study Design: Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Treatment
Official Title: Effects of Pioglitazone and Glimepiride in Hypertensive Patients - Relationship With AGE, Inflammatory Cytokines and Cardiac Markers -

Resource links provided by NLM:

Further study details as provided by Tottori University Hospital:

Primary Outcome Measures:
  • advanced glycation end-product (AGE) [ Time Frame: 24 weeks ] [ Designated as safety issue: Yes ]
  • inflammatory cytokines (TNF-alfa, IL-6 and MCP-1) [ Time Frame: 24 weeks ] [ Designated as safety issue: Yes ]
  • cardiac function (echo and BNP) [ Time Frame: 24 weeks ] [ Designated as safety issue: Yes ]

Enrollment: 16
Study Start Date: April 2007
Study Completion Date: March 2012
Primary Completion Date: December 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: glymepiride Drug: Pioglitazone
pioglitazone (15mg) once a day for 24 weeks
Other Name: actos


Ages Eligible for Study:   20 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Hypertension with insulin resistance

Exclusion Criteria:

  • Chronic systolic heart failure, ACS
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01472497

Tottori University Hospital
Yonago, Japan, 683-8504
Sponsors and Collaborators
Tottori University Hospital
Principal Investigator: Kazuhide Ogino, MD Tottori University Hospital
  More Information

Responsible Party: Kazuhide Ogino, Associate Professor, Tottori University Hospital
ClinicalTrials.gov Identifier: NCT01472497     History of Changes
Other Study ID Numbers: PIO and HTN 
Study First Received: July 21, 2011
Last Updated: June 3, 2012
Health Authority: Japan: Ministry of Health, Labor and Welfare

Keywords provided by Tottori University Hospital:
insulin resistance
oral glucose tolerance test
inflammatory cytokine

Additional relevant MeSH terms:
Insulin Resistance
Glucose Metabolism Disorders
Metabolic Diseases
Hypoglycemic Agents
Physiological Effects of Drugs

ClinicalTrials.gov processed this record on May 25, 2016