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Impact of Bean Polyphenols and Phytic Acid on Iron Absorption

This study has been completed.
Information provided by (Responsible Party):
Prof. Michael B. Zimmermann, Swiss Federal Institute of Technology Identifier:
First received: November 9, 2011
Last updated: June 18, 2012
Last verified: June 2012

Recently isolated low PA varieties (lpa) in wheat, rice, maize, barley and beans might have the potential to alleviate iron bioavailability problems associated with PA. These plants have normal phosphate levels, but reduced PA phosphate due to various modifications of the biosynthetic pathway of PA. So far lpa crops are in an early stage of development, most of them exhibiting reduced yield and seed germination. However, the lpa bean isolated by Campion and co-workers 2009 by chemical mutagenesis exhibited only 10 % of the native bean PA concentration without any defects in terms of growth and yield.

Crossing the lpa variety with bean varieties low in PP and high in iron might lead to the development of a variety which has the potential to improve the iron status of bean consuming populations.

The following study will evaluate the relative impact of PA and PP on iron absorption from beans by comparing iron absorption from four different bean varieties. Iron absorption from a bean with normal PA concentration and high PP concentration will be compared to iron absorption from a bean with normal PA and low PP concentration as well as to two lpa varieties, one with high and one with low PP concentration.

Condition Intervention
Blood Iron Isotope Enrichment
Other: 586/8x87 white
Other: 586/8x87 brown
Other: BAT 881
Other: 586/8

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single Blind (Participant)
Primary Purpose: Basic Science
Official Title: A Stable Iron Isotope Study to Investigate the Impact of Phytic Acid and Polyphenols on Iron Absorption From Beans in Humans

Resource links provided by NLM:

Further study details as provided by Prof. Michael B. Zimmermann, Swiss Federal Institute of Technology:

Primary Outcome Measures:
  • Shift in iron isotopic composition in blood after consumption of different bean varieties [ Time Frame: 1 month ]

Enrollment: 20
Study Start Date: December 2011
Study Completion Date: January 2012
Primary Completion Date: January 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: lpa with high polyphenol Other: 586/8x87 brown
2 x 50 g
Experimental: lpa with low polyphenol Other: 586/8x87 white
2 x 50 g
Experimental: control bean with low polyphenol Other: 586/8
2 x 50 g
Experimental: control bean with high polyphenol Other: BAT 881
2 x 50 g


Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Non-pregnant, non-lactating women
  • Between 18 and 40 years
  • Below 65kg

Exclusion Criteria:

  • Metabolic, chronic and gastro-intestinal disease
  • Long-term medication
  • Blood donation within 6 month before the study
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Please refer to this study by its identifier: NCT01472484

Zurich, Switzerland, 8092
Sponsors and Collaborators
Swiss Federal Institute of Technology
Principal Investigator: Richard Hurrell, Prof. Dr. University of Zurich
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Prof. Michael B. Zimmermann, Prof, Swiss Federal Institute of Technology Identifier: NCT01472484     History of Changes
Other Study ID Numbers: lpa_586/8X87
Study First Received: November 9, 2011
Last Updated: June 18, 2012

Keywords provided by Prof. Michael B. Zimmermann, Swiss Federal Institute of Technology:
lpa mutant
phytic acid
stable iron isotopes processed this record on May 25, 2017