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Impact of Bean Polyphenols and Phytic Acid on Iron Absorption

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ClinicalTrials.gov Identifier: NCT01472484
Recruitment Status : Completed
First Posted : November 16, 2011
Last Update Posted : June 19, 2012
Sponsor:
Information provided by (Responsible Party):

Study Description
Brief Summary:

Recently isolated low PA varieties (lpa) in wheat, rice, maize, barley and beans might have the potential to alleviate iron bioavailability problems associated with PA. These plants have normal phosphate levels, but reduced PA phosphate due to various modifications of the biosynthetic pathway of PA. So far lpa crops are in an early stage of development, most of them exhibiting reduced yield and seed germination. However, the lpa bean isolated by Campion and co-workers 2009 by chemical mutagenesis exhibited only 10 % of the native bean PA concentration without any defects in terms of growth and yield.

Crossing the lpa variety with bean varieties low in PP and high in iron might lead to the development of a variety which has the potential to improve the iron status of bean consuming populations.

The following study will evaluate the relative impact of PA and PP on iron absorption from beans by comparing iron absorption from four different bean varieties. Iron absorption from a bean with normal PA concentration and high PP concentration will be compared to iron absorption from a bean with normal PA and low PP concentration as well as to two lpa varieties, one with high and one with low PP concentration.


Condition or disease Intervention/treatment
Blood Iron Isotope Enrichment Other: 586/8x87 white Other: 586/8x87 brown Other: BAT 881 Other: 586/8

Study Design

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 20 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single (Participant)
Primary Purpose: Basic Science
Official Title: A Stable Iron Isotope Study to Investigate the Impact of Phytic Acid and Polyphenols on Iron Absorption From Beans in Humans
Study Start Date : December 2011
Primary Completion Date : January 2012
Study Completion Date : January 2012

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Iron
U.S. FDA Resources

Arms and Interventions

Arm Intervention/treatment
Experimental: lpa with high polyphenol Other: 586/8x87 brown
2 x 50 g
Experimental: lpa with low polyphenol Other: 586/8x87 white
2 x 50 g
Experimental: control bean with low polyphenol Other: 586/8
2 x 50 g
Experimental: control bean with high polyphenol Other: BAT 881
2 x 50 g


Outcome Measures

Primary Outcome Measures :
  1. Shift in iron isotopic composition in blood after consumption of different bean varieties [ Time Frame: 1 month ]

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Non-pregnant, non-lactating women
  • Between 18 and 40 years
  • Below 65kg

Exclusion Criteria:

  • Metabolic, chronic and gastro-intestinal disease
  • Long-term medication
  • Blood donation within 6 month before the study
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01472484


Locations
Switzerland
ETH
Zurich, Switzerland, 8092
Sponsors and Collaborators
Swiss Federal Institute of Technology
Investigators
Principal Investigator: Richard Hurrell, Prof. Dr. University of Zurich
More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Prof. Michael B. Zimmermann, Prof, Swiss Federal Institute of Technology
ClinicalTrials.gov Identifier: NCT01472484     History of Changes
Other Study ID Numbers: lpa_586/8X87
First Posted: November 16, 2011    Key Record Dates
Last Update Posted: June 19, 2012
Last Verified: June 2012

Keywords provided by Prof. Michael B. Zimmermann, Swiss Federal Institute of Technology:
beans
lpa mutant
polyphenols
phytic acid
stable iron isotopes