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Closed Loop Ventilation Strategy in Intensive Care Unit (ICU) Patients

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01472302
First Posted: November 16, 2011
Last Update Posted: March 6, 2014
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Cenk Kirakli, Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
  Purpose
Adaptive support ventilation (ASV) is a closed loop ventilation mode that can act both like PCV and PSV automatically. Some studies suggest that ASV can reduce the weaning time in ICU patients. The investigators hypothesized that using ASV from the beginning of intubation can reduce the total duration of MV and LOS in the ICU when compared to conventional modes such as PCV+PSV

Condition Intervention Phase
Respiratory Failure All Intubated Patients Device: Adaptive Support Ventilation Device: Pressure Controlled Ventilation Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Participant)
Primary Purpose: Treatment
Official Title: Effect of a Closed Loop Ventilation Strategy on Reducing the Total Duration of Mechanical Ventilation of Intubated Intensive Care Unit Patients: A Randomized Controlled Trial

Further study details as provided by Cenk Kirakli, Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital:

Primary Outcome Measures:
  • Duration of mechanical ventilation [ Time Frame: 1 year ]

Enrollment: 229
Study Start Date: April 2012
Study Completion Date: January 2014
Primary Completion Date: January 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: ASV
Adaptive Support Ventilation
Device: Adaptive Support Ventilation
Ventilation protocol according to the patients ideal body weight
Active Comparator: PCV
Pressure Controlled Ventilation
Device: Pressure Controlled Ventilation
Ventilation protocol (6-8 ml/kg tidal volume) according to our ICU

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   19 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Intubated and mechanically ventilated ICU patients for more than 24 hours

Exclusion Criteria:

  • Patient with a tracheostomy
  • Patients under home mechanical ventilation
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01472302


Locations
Turkey
Izmir Chest Diseases and Surgery Education and Research Hospital, Intensive Care Unit
Izmir, Yenisehir, Turkey, 35550
Sponsors and Collaborators
Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
Investigators
Principal Investigator: Cenk Kirakli, MD Izmir Dr. Suat Seren Chest Diseases and Surgery Training Hospital
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Cenk Kirakli, Principal investigator, Director of ICU, Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
ClinicalTrials.gov Identifier: NCT01472302     History of Changes
Other Study ID Numbers: IGCEAH-ICU 2
First Submitted: November 11, 2011
First Posted: November 16, 2011
Last Update Posted: March 6, 2014
Last Verified: March 2014

Additional relevant MeSH terms:
Respiratory Insufficiency
Respiration Disorders
Respiratory Tract Diseases