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Closed Loop Ventilation Strategy in Intensive Care Unit (ICU) Patients

This study has been completed.
Information provided by (Responsible Party):
Cenk Kirakli, Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital Identifier:
First received: November 11, 2011
Last updated: March 5, 2014
Last verified: March 2014
Adaptive support ventilation (ASV) is a closed loop ventilation mode that can act both like PCV and PSV automatically. Some studies suggest that ASV can reduce the weaning time in ICU patients. The investigators hypothesized that using ASV from the beginning of intubation can reduce the total duration of MV and LOS in the ICU when compared to conventional modes such as PCV+PSV

Condition Intervention Phase
Respiratory Failure
All Intubated Patients
Device: Adaptive Support Ventilation
Device: Pressure Controlled Ventilation
Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Participant)
Primary Purpose: Treatment
Official Title: Effect of a Closed Loop Ventilation Strategy on Reducing the Total Duration of Mechanical Ventilation of Intubated Intensive Care Unit Patients: A Randomized Controlled Trial

Further study details as provided by Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital:

Primary Outcome Measures:
  • Duration of mechanical ventilation [ Time Frame: 1 year ]

Enrollment: 229
Study Start Date: April 2012
Study Completion Date: January 2014
Primary Completion Date: January 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: ASV
Adaptive Support Ventilation
Device: Adaptive Support Ventilation
Ventilation protocol according to the patients ideal body weight
Active Comparator: PCV
Pressure Controlled Ventilation
Device: Pressure Controlled Ventilation
Ventilation protocol (6-8 ml/kg tidal volume) according to our ICU


Ages Eligible for Study:   19 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Intubated and mechanically ventilated ICU patients for more than 24 hours

Exclusion Criteria:

  • Patient with a tracheostomy
  • Patients under home mechanical ventilation
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Please refer to this study by its identifier: NCT01472302

Izmir Chest Diseases and Surgery Education and Research Hospital, Intensive Care Unit
Izmir, Yenisehir, Turkey, 35550
Sponsors and Collaborators
Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
Principal Investigator: Cenk Kirakli, MD Izmir Dr. Suat Seren Chest Diseases and Surgery Training Hospital
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Cenk Kirakli, Principal investigator, Director of ICU, Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital Identifier: NCT01472302     History of Changes
Other Study ID Numbers: IGCEAH-ICU 2
Study First Received: November 11, 2011
Last Updated: March 5, 2014

Additional relevant MeSH terms:
Respiratory Insufficiency
Respiration Disorders
Respiratory Tract Diseases processed this record on May 24, 2017