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Closed Loop Ventilation Strategy in Intensive Care Unit (ICU) Patients

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ClinicalTrials.gov Identifier: NCT01472302
Recruitment Status : Completed
First Posted : November 16, 2011
Last Update Posted : March 6, 2014
Sponsor:
Information provided by (Responsible Party):
Cenk Kirakli, Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital

Brief Summary:
Adaptive support ventilation (ASV) is a closed loop ventilation mode that can act both like PCV and PSV automatically. Some studies suggest that ASV can reduce the weaning time in ICU patients. The investigators hypothesized that using ASV from the beginning of intubation can reduce the total duration of MV and LOS in the ICU when compared to conventional modes such as PCV+PSV

Condition or disease Intervention/treatment Phase
Respiratory Failure All Intubated Patients Device: Adaptive Support Ventilation Device: Pressure Controlled Ventilation Phase 4

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 229 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Participant)
Primary Purpose: Treatment
Official Title: Effect of a Closed Loop Ventilation Strategy on Reducing the Total Duration of Mechanical Ventilation of Intubated Intensive Care Unit Patients: A Randomized Controlled Trial
Study Start Date : April 2012
Actual Primary Completion Date : January 2014
Actual Study Completion Date : January 2014

Arm Intervention/treatment
Experimental: ASV
Adaptive Support Ventilation
Device: Adaptive Support Ventilation
Ventilation protocol according to the patients ideal body weight

Active Comparator: PCV
Pressure Controlled Ventilation
Device: Pressure Controlled Ventilation
Ventilation protocol (6-8 ml/kg tidal volume) according to our ICU




Primary Outcome Measures :
  1. Duration of mechanical ventilation [ Time Frame: 1 year ]


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Ages Eligible for Study:   19 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Intubated and mechanically ventilated ICU patients for more than 24 hours

Exclusion Criteria:

  • Patient with a tracheostomy
  • Patients under home mechanical ventilation

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01472302


Locations
Turkey
Izmir Chest Diseases and Surgery Education and Research Hospital, Intensive Care Unit
Izmir, Yenisehir, Turkey, 35550
Sponsors and Collaborators
Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
Investigators
Principal Investigator: Cenk Kirakli, MD Izmir Dr. Suat Seren Chest Diseases and Surgery Training Hospital

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Cenk Kirakli, Principal investigator, Director of ICU, Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
ClinicalTrials.gov Identifier: NCT01472302     History of Changes
Other Study ID Numbers: IGCEAH-ICU 2
First Posted: November 16, 2011    Key Record Dates
Last Update Posted: March 6, 2014
Last Verified: March 2014

Additional relevant MeSH terms:
Respiratory Insufficiency
Respiration Disorders
Respiratory Tract Diseases