Adiponectin and Circulating Macrophage Phenotypes in Non-alcoholic Fatty Liver Disease (NAFLD)
Recruitment status was: Not yet recruiting
Non-alcoholic Fatty Liver Disease
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||The Relationship of Adiponectin With Circulating Macrophage Phenotypes in Non-alcoholic Fatty Liver Disease|
- For laboratory analyses, the collection of all blood samples from the study participants. [ Time Frame: Collection of blood samples in one year and analyses of data in 3 months. ] [ Designated as safety issue: No ]
|Study Start Date:||December 2011|
|Estimated Study Completion Date:||January 2013|
|Estimated Primary Completion Date:||September 2012 (Final data collection date for primary outcome measure)|
P and C
P: NAFLD patients
C: Healthy controls
In peripheral blood; monocytes and macrophages are found in two phenotype; proinflammatory M1 and anti-inflammatory M2 phenotypes.
M2 form is converted (or polarized) to M1 phenotype in various metabolic disorders such as obesity and type 2 diabetes mellitus. In addition, these forms also are related to insulin resistance and inflammation in adipose tissue.
Today, there is no study that investigate the role of adiponectin an anti-inflammatory adipokine, on macrophage polarization in non-alcoholic fatty liver disease.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01472120
|Gastroenterology Department, Gulhane School of Medicine|
|Ankara,, Turkey, 06018|
|Principal Investigator:||halil genc, MD||Gulhane Medical School|